Novel Potential Avenues for the Therapy of Tourette Syndrome: Cannabinoid- and Steroid-Based Interventions

    January 2022 in “ International review of movement disorders ”
    Marco Bortolato, Roberto Cadeddu
    Image of study
    TLDR Cannabinoid and steroid-based drugs could be new treatments for Tourette syndrome, but more research is needed to confirm their effectiveness and safety.
    The document discusses the potential use of cannabinoid- and steroid-based drugs as alternative therapies for Tourette syndrome (TS). Current treatments for TS are not consistently effective and can have significant side effects. The therapeutic potential of cannabinoids has been suggested by patient surveys and small clinical trials, although the efficacy of the main psychoactive cannabis ingredient, THC, in reducing tic severity is modest. Combining THC with other cannabinoids or related compounds may have therapeutic effects, but the use of cannabinoids in TS is controversial due to the risk of psychopathology, especially in children and adolescents. Neuroactive steroids may also play a role in TS, but clinical investigations on steroid-related drugs as therapies for tic disorders are still preliminary. Steroidogenesis inhibitors like finasteride may show promise for treating adult male TS patients, but more research is needed to determine their therapeutic value and toxicity. Overall, further research is necessary to fully understand the therapeutic potential and safety of cannabinoids and steroids for TS.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 6 results

      community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

      in Research/Science  4 upvotes 1 year ago
      Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

      community About the CBD regrowth study : just a few remarks

      in Research/Science  165 upvotes 4 years ago
      CBD in an emu and lanolin oil preparation showed a 100% increase in hair growth, but the effectiveness may partly come from the oils. Users discussed proper CBD dosage, preparation methods, and skepticism about the study's quality.

      community 11mth daily 0.5mg oral finasteride

      in Finasteride/Dutasteride  835 upvotes 1 year ago
      The user experienced significant hair regrowth with 0.5mg oral finasteride daily, despite a minoxidil allergy, and reported no side effects. They also used a keto shampoo and were satisfied with the results.

      community My microneedling journey (no min, fin, etc)

      in Microneedling  210 upvotes 1 year ago
      The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

      community Marijuana and hair loss?

       6 upvotes 9 years ago
      The conversation discusses the potential impact of marijuana on hair loss, with some users suggesting it may worsen hair loss due to hormonal changes, while others believe it might alter perception rather than cause actual thinning. The original poster uses Propecia (finasteride) and Rogaine (minoxidil) for treatment and is considering quitting marijuana to see if it affects hair health.

    Related Research

    1 / 1 results