The Hair Loss Encyclopedia

Thymosin Beta 4 Induces Hair Growth Via Stem Cell Migration And Differentiation

September 2007 in “ Annals of the New York Academy of Sciences ”

Deborah Philp, Sharleen St‐Surin, HEE‐JAE CHA, Hye‐Sung Moon, Hynda K. Kleinman, Michael Elkin

thymosin beta 4 stem cell migration stem cell differentiation follicle stem cell growth protease production

TLDR Thymosin beta 4 helps hair grow by boosting stem cell activity.

The study investigated the effects of Thymosin beta 4, a 43-amino-acid molecule, on hair growth. It was found to promote hair growth in various rat and mouse models, including a transgenic mouse overexpressing Thymosin beta 4. The mechanism involved the promotion of follicle stem cell growth, migration, differentiation, and protease production. This research provided insights into the potential of Thymosin beta 4 as a therapeutic agent for hair growth by influencing stem cell behavior.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells

research Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells

98 citations , December 2003 in “The FASEB Journal”

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin: The Absence of Type VII Collagen Is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Hair Cycle-Dependent Expression of Hepatocyte Growth Factor Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of Hepatocyte Growth Factor in Rat Hair Follicles

33 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”