TLDR Tissue stem cells originate from specific areas in organs and are vital for organ maintenance and repair.
The document discussed the developmental origin of tissue stem cells, emphasizing their crucial role in organ homeostasis and regeneration due to their self-renewal and differentiation capabilities. Technological advancements allowed for tracing cellular dynamics and lineages, revealing the origins of tissue stem cells in organs such as hair follicles, intestines, brain, skeletal muscles, and the hematopoietic system. The findings provided insights into the molecular, cellular, and biophysical foundations of stem cell formation and highlighted the coordination of stem cell fate specification with tissue topology.
7 citations
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October 2022 in “Development Growth & Differentiation” Tissue stem cells originate from specific areas in organs and are vital for organ maintenance and repair.
23 citations
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November 2018 in “Development, Growth & Differentiation” Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.
79 citations
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November 2016 in “EMBO Reports” Disruptions in mammary stem cell division can lead to cancer, but targeting these processes might help treat breast cancer.
82 citations
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March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
137 citations
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April 2015 in “Nature Reviews Molecular Cell Biology” Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.
394 citations
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October 2013 in “Nature” 854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
