Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness

This study conducted a transcriptome meta-analysis on six animal breeds, focusing on Ordos fine wool sheep, to investigate the genetic basis of wool fineness. Researchers analyzed RNA-seq datasets and identified 32 candidate genes, such as KAZALD1, MYOC, and C1QTNF6, involved in hair follicle development and hair loss regulation. The study found that different sheep breeds share a similar molecular regulatory basis for wool fineness, with 366 differentially expressed genes (DEGs) identified in Ordos fine wool sheep. Key genes like CCL24, ITGAM, and FOS were highlighted for their potential influence on wool fineness. The findings, validated using RT-qPCR, contribute to understanding the genetic basis of wool fineness, crucial for improving livestock hair's economic value and providing insights for molecular breeding strategies.