Treatment of Hereditary Hypotrichosis Simplex of the Scalp with Oral Minoxidil and Growth Factors

June 2022 in “ Dermatologic Therapy ”

Maria Vastarella, Fabrizio Martora, Jorge Ocampo-Candiani, Angela Patrì, Teresa Battista, Paola Nappa, Gabriella Fabbrocini, Mariateresa Cantelli

hereditary hypotrichosis simplex oral minoxidil growth factors nonsyndromic alopecia LIPH gene mutation congenital hypotrichosis HS minoxidil

TLDR Oral minoxidil and growth factors improved hair density and thickness in a girl with hereditary hair loss.

A 14-year-old girl with hereditary hypotrichosis simplex (HS), a rare form of nonsyndromic alopecia, showed significant improvement in hair density and thickness after 3 months of treatment with oral minoxidil (0.25 mg daily) and growth factors. HS is characterized by progressive scalp hair loss starting in childhood, often leading to near-complete baldness by the third decade. The patient, who had a LIPH gene mutation, experienced positive results, suggesting that oral minoxidil can be an effective treatment for improving hair density and thickness in congenital hypotrichosis.

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Research cited in this study

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research Isolated Autosomal Recessive Woolly Hair/Hypotrichosis: Genetics, Pathogenesis, and Therapies

9 citations , May 2021 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Topical minoxidil may help treat a rare genetic hair condition with no fully effective treatments yet.

research Bi-Allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex

55 citations , November 2018 in “American journal of human genetics”

Mutations in the LSS gene cause a rare type of hereditary hair loss.

research Prognosis and Management of Congenital Hair Shaft Disorders with Fragility—Part I

33 citations , June 2016 in “Pediatric Dermatology”

Some congenital hair disorders improve in childhood or with treatments like minoxidil and retinoids, while others like Netherton syndrome and trichothiodystrophy have a poor prognosis.

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