Gradient-Dependent Release of the Model Drug TRITC-Dextran from FITC-Labeled BSA Hydrogel Nanocarriers in the Hair Follicles of Porcine Ear Skin

    October 2016 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Ngo Bich Nga Nathalie Tran, Fanny Knorr, Wing Cheung Mak, Kwan Yee Cheung, Heike Richter, Martina C. Meinke, Jürgen Lademann, Alexa Patzelt
    TLDR The drug was successfully released into hair follicles using nanocarriers.
    The study investigated the release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin. The nanocarriers, with a size of 663 ± 48 nm, were applied topically, and their penetration and drug release were analyzed using confocal laser scanning microscopy. The results showed that TRITC-dextran penetrated deeper into the follicular ducts compared to the FITC-labeled particles, indicating successful drug release. The release was triggered by altering the concentration gradient through washing the nanocarriers, demonstrating a potential method for targeted drug delivery in hair follicles.
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