Transcutaneous Application of Ultrasound Enhances the Effects of Finasteride in Murine Model of Androgenic Alopecia

The study demonstrated that transcutaneous application of ultrasound enhanced the effects of finasteride in promoting hair growth in a murine model of androgenic alopecia. Eleven mice treated with testosterone enanthate and daily oral finasteride showed significantly more hair growth in areas exposed to ultrasound compared to unsonicated areas. The sonicated regions had a higher number and larger diameter of hair follicles, increased skin thickness, and a higher anagen/telogen ratio. The study suggests that ultrasound may increase the local effectiveness of finasteride by disrupting its binding to albumin, enhancing the drug's bioavailability. The findings indicate that ultrasound could be a promising non-invasive tool for improving localized drug delivery in androgenic alopecia treatment.