Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies

This review emphasizes the role of genetics in understanding and treating male pattern hair loss (MPHL), highlighting the identification of numerous genetic loci related to androgen signaling and WNT pathways. It suggests a shift towards genetically informed treatment strategies, using pharmacogenetic markers and polygenic scores to tailor therapies like minoxidil and 5α-reductase inhibitors. The study involved 26,607 participants and a pharmacogenetic cohort of 252 individuals, supporting the integration of genetics into therapeutic decision-making. While complete follicular restoration is unlikely, realistic outcomes include stabilization, modest regrowth, or delayed progression. Emerging therapies targeting genetic pathways and innovative approaches like RNA-based androgen receptor silencing are discussed as potential advancements. The review underscores the need for further validation and diverse cohort studies to establish clinical decision models.