Vibrissa Hair Bulge Houses Two Populations of Skin Epithelial Stem Cells Distinct by Their Keratin Profile

December 2007 in “ The FASEB journal ”

Danielle Larouche, Xuemei Tong, Julie Fradette, Pierre A. Coulombe, Lucie Germain

vibrissa hair follicles epithelial stem cells keratin profiles K5 K15 K17 K19 K14 basal layer suprabasal layers hair follicle stem cells skin tissue engineering hair follicles stem cells keratin

TLDR There are two types of stem cells in rodent hair follicles, each with different keratin proteins.

The study identified two distinct populations of skin epithelial stem cells in the vibrissa hair bulge, differentiated by their keratin profiles. This discovery provided insights into the complexity of stem cell niches in hair follicles and their potential roles in hair growth and skin regeneration. The research highlighted the role of specific keratins in cellular processes and the potential of outer root sheath cells to regenerate epidermis and contribute to hair follicle formation.

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Research cited in this study

15 / 15 results

research Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion

169 citations , May 2006 in “Genes & Development”

Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.

research A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue

31 citations , April 2004 in “Journal of Investigative Dermatology”

A new mouse gene, Keratin 17n, is mainly found in nail tissue and may explain why mice without Keratin 17 don't have nail issues.

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

60 citations , December 2003 in “Journal of Investigative Dermatology”

K6hf is found in specific parts of hair follicles, nails, and tongue, and is linked to hair growth and structure.

research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

87 citations , November 2002 in “Journal of Investigative Dermatology”

research Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia

122 citations , June 2002 in “Genes & Development”

Keratin 17 is crucial for early hair strength and cell survival.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

Keratin 17 is important for skin development and may help define skin cell types.

research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage

441 citations , May 1996 in “Journal of Cell Science”

Keratin 19 helps identify skin stem cells, with its presence varying by body location, age, and culture stage.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)

187 citations , May 1988 in “Differentiation”

Trichocytic cytokeratins are found in hair, nails, tongue, and thymus cells, showing complex regulation in tissue development.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

Related Research

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research Expression of Caspase-14 and Keratin-19 in the Human Epidermis and Appendages During Fetal Skin Development

19 citations , February 2013 in “Archives of Dermatological Research”

research Delayed Wound Healing in Keratin 6a Knockout Mice

149 citations , July 2000 in “Molecular and Cellular Biology”

Keratin 6a is important for quick wound healing from hair follicles.

research Expression of MK6a Dominant-Negative and C-Terminal Mutant Transgenes in Mice Has Distinct Phenotypic Consequences in the Epidermis and Hair Follicle

30 citations , October 1999 in “Differentiation”

Mutant MK6a transgenes in mice cause blistering, hair loss, and potential human alopecia.

research Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin

25 citations , September 1995 in “Biochemistry and Cell Biology”

High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.

research Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin

94 citations , October 1994 in “The Journal of Cell Biology”

Too much keratin 16 in mice skin causes abnormal skin thickening and structure.

research Architecture of Reconstructed Epidermis on Collagen Lattices Varies According to the Method Used: A Comparative Study

9 citations , January 1990 in “Skin Pharmacology and Physiology”

The method and source of keratinocytes affect the structure of reconstructed skin.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

research Chapter 3: Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis

81 citations , January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology”

Keratins change and are modified differently in skin layers and body parts.

Vibrissa Hair Bulge Houses Two Populations of Skin Epithelial Stem Cells Distinct by Their Keratin Profile

Research cited in this study

research Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion

research A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

research Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

research Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

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research Expression of Caspase-14 and Keratin-19 in the Human Epidermis and Appendages During Fetal Skin Development

research Delayed Wound Healing in Keratin 6a Knockout Mice

research Expression of MK6a Dominant-Negative and C-Terminal Mutant Transgenes in Mice Has Distinct Phenotypic Consequences in the Epidermis and Hair Follicle

research Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin

research Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin

research Architecture of Reconstructed Epidermis on Collagen Lattices Varies According to the Method Used: A Comparative Study

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

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