TLDR Too much keratin 16 in mice skin causes abnormal skin thickening and structure.
The study found that overexpression of the human K16 gene in transgenic mice led to abnormal keratinization in the hair follicle outer root sheath and proximal epidermis, resulting in hyperproliferation and increased thickness of both living and cornified skin layers. This was due to a reorganization of keratin filaments in postmitotic keratinocytes, which disrupted keratinocyte cytoarchitecture and altered desmosomes. The findings suggested that high levels of K16, along with K6 and K17, could reorganize keratin filaments, interfering with normal terminal differentiation in skin epithelial cells.
A user plans to experiment with creating new hairfollicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.
A gel of keratin microspheres promotes hairfollicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.
Scientists have successfully grown functional hairfollicles in the lab, marking a significant advancement in hair regeneration research. A user shared their personal experience with hair loss treatments, including Minoxidil and Finasteride, and plans to share a detailed protocol for hair restoration.
Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.
Hairfollicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.
