December 2021 in “Figshare” The study explored the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis, particularly under occlusal hypofunction conditions. Researchers used RNA sequencing on 34 human teeth and found that BBS7 expression was downregulated in hypofunctional PDL, leading to changes in cell number, collagen fiber alignment, blood vessel diameter, and primary cilia appearance. BBS7 was shown to be crucial for Sonic hedgehog (Shh) signaling activity, which is important for PDL homeostasis. Knockdown of BBS7 resulted in suppressed cell migration and angiogenesis in vitro, underscoring its role in periodontal health. However, the specific association of each BBS family gene with occlusal force was not clearly understood.
December 2021 in “Figshare” The study explored the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis, particularly under occlusal hypofunction conditions. Researchers used RNA sequencing on 34 human teeth and found that BBS7 expression was downregulated in hypofunctional PDL, which correlated with changes in cell number, collagen fiber alignment, blood vessel diameter, and primary cilia appearance. The study highlighted that Sonic hedgehog (Shh) signaling, important for tissue regeneration, was linked to BBS7 expression. BBS7 knockdown suppressed cell migration and angiogenesis in vitro, indicating its essential role in PDL homeostasis through Shh signaling. However, the specific link between BBS family genes and occlusal force remained unclear.
December 2021 in “Figshare” The study investigated the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis under occlusal hypofunction conditions. RNA sequencing of 34 human teeth revealed that BBS7 expression was downregulated in hypofunctional PDL, leading to atrophic changes such as reduced PDL cell numbers, altered collagen fiber alignment, and decreased blood vessel diameter. The study found that Sonic hedgehog (Shh) signaling activity was closely linked to BBS7 expression, and BBS7 knockdown suppressed cell migration and angiogenesis in vitro. These findings suggested that BBS7 was crucial for maintaining Shh signaling and PDL homeostasis.
December 2021 in “Figshare” The study investigated the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis under occlusal hypofunction conditions. RNA sequencing of 34 human teeth revealed that BBS7 expression was downregulated in hypofunctional PDL, leading to atrophic changes such as reduced PDL cell numbers, altered collagen fiber alignment, and decreased blood vessel diameter. The study found that Sonic hedgehog (Shh) signaling activity was closely linked to BBS7 expression, and BBS7 knockdown suppressed cell migration and angiogenesis in vitro. These findings suggested that BBS7 is crucial for maintaining Shh signaling activity and PDL homeostasis.
December 2021 in “Figshare” The study explored the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis, particularly under conditions of occlusal hypofunction. RNA sequencing of 34 human teeth showed that BBS7 expression was downregulated in hypofunctional PDL, resulting in atrophic changes such as reduced PDL cell numbers, altered collagen fiber alignment, and decreased blood vessel diameter. The research highlighted that Sonic hedgehog (Shh) signaling activity was closely linked to BBS7 expression, and BBS7 knockdown suppressed cell migration and angiogenesis in vitro. The findings suggested that BBS7 was essential for maintaining Shh signaling and PDL homeostasis, although the specific link between BBS family genes and occlusal force was not fully understood.
