Current Topics on Vitamin D: The Vitamin D Functions in Keratinocytes and Its Therapeutic Applications

March 2015 in “ PubMed ”

Shun Sawatsubashi

vitamin D 1,25-dihydroxyvitamin D calcium keratinocytes vitamin D receptor psoriasis hair follicles skin homeostasis

TLDR Vitamin D helps treat psoriasis by promoting skin cell differentiation and reducing growth.

The review discussed the role of vitamin D, specifically 1,25 (OH)2D, in promoting epidermal keratinocyte differentiation and preventing proliferation, which was utilized in treating psoriasis. Despite its clinical applications, the exact mechanism of vitamin D's action on keratinocytes was not well understood. The review highlighted that while calcium and vitamin D receptor signaling pathways had overlapping effects on keratinocyte differentiation, their impact on hair follicles differed. The discussion focused on how vitamin D and its receptor contributed to maintaining skin and hair follicle homeostasis.

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research Current Topics on Vitamin D: The Vitamin D Functions in Keratinocytes and Its Therapeutic Applications

1 citations , March 2015 in “PubMed”

Vitamin D helps treat psoriasis by promoting skin cell differentiation and reducing growth.