The Role of Vitamin D and Its Receptor in Hair Follicle Biology

December 2017 in “ Elsevier eBooks ”

Marie B. Demay, Marie B. Demay

vitamin D receptor VDR hair follicle biology alopecia cyclic regeneration CYP27B1 epidermal keratinocytes 1,25(OH)2D vitamin D hair loss

TLDR Vitamin D receptor is crucial for hair growth, not vitamin D itself.

The study discussed the role of the vitamin D receptor (VDR) in hair follicle biology, highlighting that mutations in the VDR in both humans and mice led to alopecia due to impaired cyclic regeneration of hair follicles. Interestingly, alopecia was not observed in cases of vitamin D deficiency or absence of the enzyme CYP27B1, which is necessary for activating vitamin D metabolites. This indicated that, unlike the effects of the VDR on epidermal keratinocytes, which depended largely on its ligand, the VDR's role in hair follicle regeneration did not require the active form of vitamin D, 1,25(OH)2D.

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Research cited in this study

23 / 23 results

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12 citations , December 2016 in “The FASEB Journal”

Lack of vitamin D receptor causes hair loss in mice by allowing certain genes to overactivate.

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18 citations , March 2016 in “Journal of Investigative Dermatology”

Vitamin D and calcium are essential for normal hair growth.

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Vitamin D receptor is essential for hair growth signaling.

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Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

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25 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

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127 citations , January 2008 in “PloS one”

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

research Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk

102 citations , July 2007 in “Genes & Development”

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

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143 citations , May 2007 in “Proceedings of the National Academy of Sciences”

Vitamin D receptor is crucial for normal hair growth and preventing hair loss.

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78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

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144 citations , December 2004 in “Molecular Endocrinology”

The vitamin D receptor is essential for normal hair growth, even without its usual binding.

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Vitamin D receptor and hairless protein are essential for hair growth.

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277 citations , July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

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180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is crucial for normal skin and hair growth.

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115 citations , December 2001 in “Endocrinology”

Expressing the human vitamin D receptor in skin cells prevents hair loss in certain mice.

The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor

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Activated LEF/TCF complexes are crucial for hair development and cycling.

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Activating the Sonic hedgehog gene in mice can start the hair growth phase.

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β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.

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519 citations , October 1998 in “Endocrinology”

Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

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412 citations , January 1998 in “Science”

A mutation in the human hairless gene causes alopecia universalis.