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GlossaryCYP27B1

enzyme converting inactive vitamin D to its active form

CYP27B1, also known as 25-hydroxyvitamin D3 1-alpha-hydroxylase, is an enzyme that plays a crucial role in the metabolism of vitamin D. It converts inactive vitamin D into its active form, calcitriol, which is essential for calcium absorption and bone health. This enzyme is important for maintaining proper levels of calcium and phosphate in the blood, which are vital for normal bone formation and maintenance.

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Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice

research Nongenomic effects of 1α,25-dihydroxyvitamin D 3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

11 citations , January 2017 in “Biochemical and biophysical research communications”

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

research Genetic Disorders and Defects in Vitamin D Action

151 citations , June 2010 in “Endocrinology and metabolism clinics of North America”

Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.

research Extraskeletal actions of vitamin D

119 citations , July 2016 in “Annals of the New York Academy of Sciences”

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.