WNT5A Drives Interleukin-6-Dependent Epithelial-Mesenchymal Transition via the JAK/STAT Pathway in Keloid Pathogenesis

    January 2022 in “ Burns & Trauma ”
    Young In Lee, Jung Eun Shim, Jihee Kim, Won Jai Lee, Jae Woo Kim, Kee‐Hyun Nam, Ju Hee Lee
    TLDR WNT5A contributes to keloid scars by promoting cell changes through specific signaling pathways.
    The study investigated the molecular drivers of keloid pathogenesis, focusing on the role of WNT5A in epithelial-mesenchymal transition (EMT). Using an animal model with C57BL/6 mice, the research demonstrated that silencing WNT5A reduced EMT-like phenotypes in keratinocytes. The findings suggested that intercellular communication via the WNT5A and STAT pathways contributed to EMT-like phenomena in keloid pathogenesis. Specifically, IL-6 secreted from WNT5A-activated fibroblasts activated the JAK/STAT signaling pathway in adjacent keratinocytes, leading to the expression of EMT markers. Understanding the role of WNT5A in EMT could aid in developing targeted treatments for keloid scars.
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