Timely Wound Healing Is Dependent on Endothelial but Not on Hair Follicle Stem Cell Toll-Like Receptor 2 Signaling

    May 2022 in “ Journal of Investigative Dermatology ”
    Luyang Xiong, Michael McCoy, Rakhilya Murtazina, Eugene A. Podrez, Tatiana V. Byzova
    TLDR Endothelial TLR2 is crucial for timely wound healing, but HFSC TLR2 is not needed.
    The study found that Toll-like receptor 2 (TLR2) signaling in endothelial cells was crucial for timely wound healing due to its role in promoting angiogenesis, as evidenced by delayed wound healing and reduced proangiogenic activity in Tlr2-knockout mice. In contrast, TLR2 in hair follicle stem cells (HFSCs) was not necessary for their proliferation or wound healing potential. The research involved 22 mice per group and highlighted the essential role of endothelial TLR2 in tissue regeneration, while HFSC TLR2 was dispensable.
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