Histopathological Investigation of Wound Healing Activities of Lucilia Sericata Larva and Achillea Sintenisii Extract Combinations in Diabetic Rat Wound Model

The study investigated the wound healing effects of combining Lucilia sericata larva secretions and Achillea sintenisii extract in a diabetic rat model. By Day 12, the combination treatment group (DM + DA) showed the highest wound contraction rate of 92.91%, significantly outperforming other groups. Histological evaluations confirmed superior tissue repair in the DM + DA group, with enhanced epithelialization, fibroblast density, collagen deposition, angiogenesis, and hair follicle regeneration. These findings suggest that the combined therapy offers a synergistic effect, potentially leading to effective and affordable natural products for chronic wound care in both veterinary and human medicine.