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Glossary12-O-Tetradecanoylphorbol-13-acetate

chemical compound used to activate protein kinase C (PKC)

12-O-Tetradecanoylphorbol-13-acetate, commonly known as TPA, is a chemical compound used in biological research to activate protein kinase C (PKC). It is often employed in studies related to cell differentiation, proliferation, and apoptosis, making it a valuable tool for understanding various cellular processes and diseases, including cancer and skin conditions.

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research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

Induction of Dark Keratinocytes by 12-O-Tetradecanoyl-Phorbol-13-Acetate and Mezerein as an Indicator of Tumor-Promoting Efficiency

research Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency

77 citations , January 1980 in “Carcinogenesis”

TPA is about 50 times more effective at promoting tumors than MZ.

research Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors

37 citations , January 1986 in “Carcinogenesis”

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

research Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate

26 citations , January 1992 in “Carcinogenesis”

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

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