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GlossaryDiacylglycerol O-Acyltransferase 1

enzyme that catalyzes the final step in triglyceride synthesis

Diacylglycerol O-Acyltransferase 1 (DGAT1) is an enzyme that plays a crucial role in the body's ability to store fat. It catalyzes the final step in the synthesis of triglycerides, which are the main form of stored energy in fat cells. This enzyme is important for energy metabolism and has been studied for its potential links to obesity and metabolic disorders.

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MEK and BRAF Inhibitors Augment the Production and Accumulation of Sebum in Hamster Sebocytes

research 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes

April 2016 in “Journal of Investigative Dermatology”

MEK and BRAF inhibitors increase sebum production and accumulation, which could cause acne-like side effects.

The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner

research The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner

May 2025 in “Experimental Dermatology”

Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.

research The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

258 citations , July 2005 in “Journal of lipid research”

DGAT1 enzyme helps make diacylglycerols, waxes, and retinyl esters.

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

31 citations , July 2012 in “Journal of Lipid Research”

ACBP is crucial for healthy skin in mice.

Unraveling the Link Between Insulin Resistance and Androgen Excess

research Unravelling the link between insulin resistance and androgen excess

December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

AKR1C3 could be a treatment target for metabolic issues in PCOS.

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