research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes
Researchers made two new compounds that could be used for medicine.
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research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond
The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.
research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride
Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
research A high-performance liquid chromatography–tandem mass spectrometry assay of the androgenic neurosteroid 3α-androstanediol (5α-androstane-3α,17β-diol) in plasma
Testosterone increases 3α-androstanediol levels, which can be blocked by finasteride.
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a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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Hair TransplantHair Loss TreatmentsDiolaser of Puerto Rico- San JuanSan Juan · PR - 23Hair SystemsDIOLOI - Perücken & Haarteile in KölnKöln, Nordrhein Westfalen · DE
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Hair Transplant SurgeonDr. Dirlene Melo Palmeira Roth
São José dos Campos, SP, Brazil
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Berlin, Berlin, Germany
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Fatih, Türkiye
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Mönchengladbach, Nordrhein Westfalen, Germany
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Irfan Dilek
Dortmund, Nordrhein Westfalen, Germany
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Hair Loss SpecialistDivya Dileep, BAMS
Thrissur, Kerala, India
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