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Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum Japonicum: Glycosylation of Methyl Gallate with Ulosyl Bromides

research Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum japonicum : Glycosylation of Methyl Gallate with Ulosyl Bromides

June 2025 in “Natural Product Communications”

Researchers created 10 new compounds similar to cercidin, which could lead to new antibiotics.

research Androgen antagonists in androgen target tissues

27 citations , January 1984 in “Pharmacology & Therapeutics”

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

Compound 15a was effective in inhibiting 5α-reductase.

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

Scientists made two new chemicals that might help treat diseases caused by male hormones.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

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community 2 years. More hair. Dut, Oral Min, RU, Niz

in Progress Pictures 181 upvotes 2 years ago

A user's two-year hair regrowth journey using 0.5 mg Dutasteride, 5mg oral Minoxidil, 0.75ml of 8% RU58841, and Nizoral shampoo a few times a week. Other users suggest adding microneedling and topical Minoxidil for better results.

community 2% Ketoconazole/Nizoral Daily?

in Ketoconazole 11 upvotes 8 months ago

Using 2% ketoconazole daily can dry out the scalp; 1-2 times a week is recommended. Combining ketoconazole with treatments like minoxidil, alfatradiol, and fluridil can help manage hair loss effectively.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 2 years ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Has anyone else had much worse hair from excessive use of Nizoral?

in Ketoconazole 19 upvotes 1 year ago

Excessive use of Nizoral can lead to dry, brittle hair and is not recommended more than 1-2 times a week. Users suggest using conditioner to mitigate dryness and note that Nizoral is more effective for treating fungal issues rather than regrowing hair.

community Completely obliterated my diffuse thinning without Finasteride w/ pictures

in Journals / Progress Pictures 205 upvotes 1 year ago

The user improved diffuse thinning without finasteride by using minoxidil foam, cold showers, gentle hair drying, 2% ketoconazole, sulfate-free tea tree oil shampoo, dermastamping, and supplements like Omega-3, Vitamin-D, Biotin, Keratin, Collagen, B3, Zinc, and Magnesium. The regimen was followed for about six months under dermatologist guidance.

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