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GlossaryAndrogen-Dependent

biological process influenced by male sex hormones

Androgen-dependent refers to biological processes or conditions that are influenced or regulated by androgens, which are male sex hormones like testosterone. For example, androgen-dependent hair loss, also known as androgenetic alopecia, occurs when hair follicles shrink due to the effects of these hormones, leading to thinning hair or baldness. This term is crucial in understanding conditions that are influenced by hormonal changes, particularly in the context of hair growth and loss.

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research Androgen-associated and androgen-independent causes of alopecia and acne in women. Literature review

1 citations , May 2020 in “Reproductive Endocrinology”

The document concludes that hair loss and acne in women can be due to both androgen-related and unrelated causes, requiring a collaborative treatment approach.

research Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene

26 citations , September 2010 in “Experimental Dermatology”

Two gene areas linked to male pattern baldness found, more research needed.

research 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

Dihydrotestosterone (DHT) increases oil production in skin cells by activating mTOR, and mTOR inhibitors can reduce this effect.

research Abstract 5561: 20(S)-Protopanaxadiol-aglycone downregulates full-length and ligand-independent splice variants of androgen receptor

April 2011 in “Cancer Research”

20(S)-Protopanaxadiol-aglycone may help prevent and treat prostate cancer by reducing androgen receptor activity.

research Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line

11 citations , June 2016 in “European Journal of Medicinal Chemistry”

Compounds 6f and 6g effectively stop prostate cancer cell growth without harming healthy cells.

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Community Join

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community Dr. Rassman vs Kevin Mann on Eucapil

in Treatment 4 upvotes 5 years ago

Eucapil is discussed as a potential hair loss treatment with some believing it to be effective, though its efficacy compared to finasteride is debated. It is considered an anti-androgen treatment, often used alongside other treatments like minoxidil and finasteride, but lacks independent studies to fully support its effectiveness.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

in Research/Science 294 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 3 years ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 484 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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