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Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

Punica granatum leaf extract may help treat skin fibrosis by reducing inflammation and oxidative stress.

research Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

October 2025 in “Cell Proliferation”

IL10_ApoEVs improve skin healing and reduce scarring.

research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

research Supplementary Material for: The Role of Fibrosis in Androgenetic Alopecia: Mechanisms and Implications

January 2025

Combining anti-androgenic, anti-inflammatory, and anti-fibrotic treatments may improve hair loss outcomes.

research Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis

3 citations , September 2024 in “The FASEB Journal”

Dermal white adipose tissue helps regulate hair growth, protect skin, and aid wound healing.

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community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

in Research/Science 58 upvotes 4 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community dunno if it's growing anything but it's making my scalp red

in Technology 182 upvotes 3 years ago

Hair loss and potential treatments, primarily focusing on Finasteride and Minoxidil. Other solutions discussed include PRP, dermarolling, LLP, and scalp tension relief.

community Anti-oxidants that reverse hairloss?

in Research/Science 90 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

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