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GlossaryATAC-seq

technique identifies open chromatin regions to study gene regulation

ATAC-seq, or Assay for Transposase-Accessible Chromatin using sequencing, is a technique used to study the accessibility of chromatin, which is the material that makes up chromosomes. By identifying regions of DNA that are open and accessible, ATAC-seq helps researchers understand which parts of the genome are active and potentially involved in gene regulation. This method is valuable for studying gene expression patterns in various biological contexts, including development, disease, and cellular responses.

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research A Multi-Omics Approach to Identifying Factors Involved in Hair Follicle Growth and Development

April 2023 in “Journal of Investigative Dermatology”

The research found that certain factors in hair follicle cells control hair growth and development, and these could be used to create new treatments for hair loss.

Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation

research Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Key skin cell regulators and gene organization changes are crucial for skin cell development and could help treat skin disorders.

Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.

research Promotion of Hair Growth in Alopecia Areata by Topical Treatment of HDAC Inhibitors

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.

research Characterization of Ectomesenchyme as an Origin of Epidermal Stem Cells

April 2023 in “Journal of Investigative Dermatology”

Ectomesenchyme is a key source of skin stem cells.

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community Will Pp405 be the Ozempic of bald Guys

in Research/Science 99 upvotes 6 days ago

PP405 is being discussed as a potential hair loss treatment, possibly more effective than minoxidil. There are concerns about its effectiveness and product contamination, but some users report early signs of hair regrowth.

community Who else is looking forward to full phase 2 results of PP405?

in Chat 59 upvotes 1 week ago

PP405 is a potential hair loss treatment showing promise, especially for men with severe balding. Some are hopeful it will be a game-changer for those who cannot tolerate finasteride or minoxidil, despite skepticism about the outcomes.

community Is pp405 actually the cure ? Just how exciting is it ?

in Research/Science 38 upvotes 1 month ago

PP405 is a promising hair growth stimulant but not a cure for advanced hair loss, as it may only help dormant follicles. Treatments like Minoxidil, Finasteride, and Dutasteride are discussed, with emphasis on early intervention for effectiveness.