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GlossaryATP-Binding Cassette Transporters

proteins that use ATP to move molecules across cell membranes

ATP-Binding Cassette (ABC) Transporters are a large family of proteins that use the energy from ATP (adenosine triphosphate) to transport various molecules across cellular membranes. These transporters play crucial roles in processes like drug resistance, lipid transport, and the movement of metabolic products, making them essential for maintaining cellular function and homeostasis.

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Differential Expression and Functionality of ATP-Binding Cassette Transporters in the Human Hair Follicle

research Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle

25 citations , November 2014 in “British Journal of Dermatology”

Certain transporters are found in human hair follicles and may affect hair growth and loss.

Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

research Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle

13 citations , January 2021 in “Histochemistry and Cell Biology”

Cholesterol transport in hair follicles decreases from growth to regression phase.

research Cantú Syndrome Is Caused by Mutations in ABCC9

148 citations , May 2012 in “The American Journal of Human Genetics”

Cantú syndrome is caused by mutations in the ABCC9 gene.

Novel Adenosine Triphosphate-Binding Cassette, Subfamily A, Member 12 Mutations Associated with Congenital Ichthyosiform Erythroderma

research Novel adenosine triphosphate (ATP)-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma

11 citations , September 2011 in “British Journal of Dermatology”

New ABCA12 gene mutations were linked to a skin condition with scaling and hair loss, and a treatment helped with hair loss in a related case.

The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

5 citations , September 2022 in “Molecular pharmacology”

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

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