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GlossaryFOXC2

gene involved in tissue development and hair follicle regulation

FOXC2 is a gene that encodes a protein involved in the development and function of various tissues, including the formation of blood vessels and the regulation of fat storage. Mutations in FOXC2 can lead to conditions like lymphedema-distichiasis syndrome, which is characterized by swelling due to fluid retention and the presence of extra eyelashes. This gene also plays a role in hair follicle development and can impact hair growth and health.

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research Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

142 citations , February 2016 in “Science”

Foxc1 helps keep hair follicle stem cells inactive, preventing hair loss.

research Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes

5 citations , October 2020 in “Frontiers in Cell and Developmental Biology”

Reducing FOXA2 in skin cells lowers their ability to grow hair.

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

May 2021 in “Experimental Cell Research”

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

research Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

2 citations , March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hairless mammals have genetic changes in both their protein-coding and regulatory sequences related to hair.

research Aging, alopecia, and stem cells

42 citations , February 2016 in “Science”

The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.

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