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GlossaryEpidermal Layers

multiple strata of cells forming the skin's outermost part

Epidermal layers refer to the multiple strata of cells that make up the outermost part of the skin, known as the epidermis. These layers include, from the deepest to the most superficial, the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum (only in thick skin), and stratum corneum. Each layer has distinct functions, such as cell regeneration, protection against pathogens, and the formation of a barrier to prevent water loss.

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research Long-term follow-up of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension

177 citations , November 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

Transplantation is effective for stable leucoderma but not for progressive, widespread vitiligo vulgaris.

research Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy

31 citations , September 2016 in “PLoS ONE”

Cell division orientation varies by body site and is linked to epidermal thickness and cell density.

research Basal cells in the epidermis and epidermal differentiation

June 2021 in “Research Square (Research Square)”

The exact identity of skin stem cells and how skin cells differentiate is not fully known.

research Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour

28 citations , September 2013 in “European Journal of Histochemistry”

Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.

research Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The case of a 78 year old man who accidentally regrew his hair (published in the British Medical Journal)

in Chat 213 upvotes 9 months ago

A 78-year-old man regrew hair after suffering burns, suggesting that injury-induced healing processes might trigger hair growth. Microneedling and other treatments like minoxidil and finasteride are discussed as potential methods to stimulate similar regrowth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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