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5 / 1000+ resultsresearch Fully Functional Hair Follicle Organ Regeneration Using Organ-Inductive Potential Stem Cells With an Accessory Mesenchymal Cell Population in an In Vitro Culture System
This study demonstrates the successful regeneration of fully functional hair follicles using organ-inductive potential stem cells combined with an accessory mesenchymal cell population in an in vitro culture system. Researchers identified a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, from the boundary zone of the epithelial stem cell niche, which plays a crucial role in promoting the hair cycle's downgrowth phase. By reconstituting hair follicle germs from bulge region-derived epithelial stem cells, dermal papillae, and mesenchymal cells, the study achieved full-size hair follicle regeneration and hair cycling both in vitro and after skin transplantation. This research advances the understanding of adult organ-inductive potential stem cells and their niches, contributing to the fields of basic and medical science related to organ morphogenesis and the adult hair cycle.
research Hair Follicle Reconstruction and Stem Cells
Stem cells could improve hair growth and new treatments for baldness are being researched.
research Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells
Stem cells rearrangement regenerates functional hair follicles, potentially treating hair loss.
research Functional Hair Follicle Regeneration
Scientists made working hair follicles using stem cells, helping future hair loss treatments.
research Engineering the Niche for Hair Regeneration: A Critical Review
Further research is needed to improve hair regeneration using stem cells and nanomaterials.
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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
community A Theory on Why Microneedling Works
Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.
community OFFICIAL Multi-Center Verteporfin Trial Recruitment
Recruitment for a verteporfin trial and a separate hair cloning trial using verteporfin and other methods is underway, with locations in Jordan, NYC, Beverly Hills, and Memphis. Dr. Bloxham is conducting the hair cloning trial, and interested participants are encouraged to contact him directly.
community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells
PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.
community DHT Harms Scalp Microbiome: DHT Itch is REAL
Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.