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Glossaryc-Jun

protein regulating gene expression, affecting cell processes and hair growth

c-Jun is a protein that plays a crucial role in regulating gene expression, which means it helps control which genes are turned on or off in a cell. It is part of the AP-1 (activator protein-1) transcription factor complex and is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. In the context of hair and alopecia, c-Jun can influence hair follicle development and cycling, potentially impacting hair growth and loss.

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Research

5 / 1000+ results

research Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis

138 citations , April 2003 in “Carcinogenesis”

2-Methoxyestradiol causes cancer cell death by activating specific pathways, but androgens can block this effect.

Stress-Induced c-Jun-Dependent Vitamin D Receptor Activation Dissects the Non-Classical VDR Pathway from the Classical VDR Activity

research Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity

31 citations , January 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

18 citations , October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

Dynamic Changes in Fibroblast Subpopulations Drive Development of Radiation-Induced Skin Fibrosis Through the Fra/c-Jun Pathway

research 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway

April 2023 in “Journal of Investigative Dermatology”

Radiation treatment causes skin fibrosis by increasing certain fibroblast subpopulations, but using a c-Jun inhibitor or fat grafting can reduce this effect.

research Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

October 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

DA-9401 can protect against finasteride-induced reproductive damage in rats.

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community Oral: 1.2mg Fin, 3mg Min, 2.5mg Biotin, 11 mg Vit B5, 2.5mg Vit B6, 100mg Vit C. Topical serum: Batana, Rosemary, Castor oils, Rice water, and more Biotin

in I'm Starting Treatment 3 months ago

A user started a hair loss treatment 6 weeks ago using oral finasteride, minoxidil, biotin, vitamins B5, B6, and C, along with a topical serum containing batana, rosemary, castor oils, rice water, and more biotin. They are hoping to see progress by June-July.

community C’est terrible - at my wits end

in Female 450 upvotes 2 years ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community My hairloss recovery, March 2025-present

in Journals / Progress Pictures 82 upvotes 1 year ago

A 24-year-old male started using 1 mg finasteride and topical minoxidil for hair loss in February 2025. By June 2025, he noticed improvement in his right temple but experienced thinning at the crown and continued shedding.

community Nothing's working, I feel depressed, also hopeless for the first time

in Update 100 upvotes 3 years ago

A user's experience with hair loss treatments, including Finasteride, Minoxidil, Nizoral Shampoo, Rosemary Oil, Vitamin D, Biotin, Vitamin C, Zinc and Dermarolling, that have not been successful over the past 14 months. Other users gave advice on how to cope with the issue, such as exercising, changing mindset, and shaving their head.

community Crown slowly coming back from the dead

in Is this regrowth? 401 upvotes 9 months ago

A user shared their hair regrowth journey using a comprehensive treatment plan including oral minoxidil, oral dutasteride, topical minoxidil, Nizoral shampoo, microneedling, and various supplements. They reported noticeable improvement in their crown area after 4.5 months, with only minor side effects like forehead pimples.

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