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mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth
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learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Sulforaphane
compound from cruciferous vegetables has some mild effects on DHT
learn PP405
mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials
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research Re: Long-Term Consequences of Finasteride vs Placebo in the Prostate Cancer Prevention Trial
Finasteride reduces the need for prostate surgery but may increase the risk of depression and persistent sexual side effects.
research Efficacy of Scalp Cooling System Versus Chemical Cooling Cap in Preventing Chemotherapy-induced Alopecia in Breast Cancer (COHAIR Study): a prospective randomized trial
The COHAIR study, a prospective randomized trial, compared the efficacy of a scalp cooling system and a chemical cooling cap in preventing chemotherapy-induced alopecia (CIA) in 152 breast cancer patients. Results showed that hair preservation success rates were 74.5% for the scalp cooling system and 71.2% for the chemical cooling cap, with both methods demonstrating good tolerability. While scalp cooling was more effective during early anthracycline treatment, the chemical cooling cap resulted in lower anxiety scores and better quality of life (QoL). Disease-free survival was similar between the two groups.
research Persistent major alopecia following adjuvant docetaxel for breast cancer: incidence, characteristics, and prevention with scalp cooling
Scalp cooling effectively prevents severe hair loss in breast cancer patients treated with docetaxel and is safe.
research 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice
5-Alpha reductase inhibitors may prevent prostate cancer but are not widely used due to concerns about trial relevance and potential risks, and more research is needed to confirm long-term benefits.
research Finasteride-its impact on sexual function and prostate cancer
Finasteride reduces prostate cancer risk but may affect ejaculatory volume and requires careful consideration for young men.
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5 / 1000+ resultscommunity Kintor Pharma Announces Positive Top-line U.S. Phase I Trial Results of GT20029, the World’s First Topical Use PROTAC Compound
The conversation discusses positive initial trial results for GT20029, a topical compound for hair loss that degrades androgen receptors, potentially requiring only weekly application. Participants express hope for this treatment to be more effective and convenient than current options like Minoxidil, Finasteride, and RU58841.
community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial
Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.
community Kintor Pharma Announces Completion of First Patient Enrollment in Phase II Clinical Trial of GT20029 for Treatment of Androgenetic Alopecia in China.
Kintor Pharma has started a Phase II trial in China for GT20029, a potential new treatment for hair loss. Participants are discussing the significance, potential release dates, and comparing it to other treatments and technologies like stem cell hair transplants and SAMIRNA.
community Realistically, how much PP405 will cost?
PP405 is in phase 2 trials for hair loss, with discussions on its cost and effectiveness compared to minoxidil and finasteride. Users are skeptical about its efficacy and timeline, with hopes for market release by 2027.
community The amazing fast pace of PP405.
PP405 is a new hair loss treatment advancing quickly in trials, generating excitement and skepticism about its effectiveness and marketing claims. Some see it as a potential alternative to minoxidil and finasteride, but concerns about long-term effects and the need for DHT blockers persist.