2 citations
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August 2023 in “Journal of Endocrinological Investigation” This study investigates the impact of maternal androgen excess on cardiac health in offspring, using pregnant mice injected with dihydrotestosterone (DHT). Results show that excessive androgen exposure in utero leads to thinner ventricular walls and decreased cardiomyocyte numbers in fetal offspring, causing cardiac hypertrophy and compromised cardiac function in adulthood. The study identifies that the androgen metabolite androsterone significantly increases in fetal heart tissue, leading to decreased phosphorylated retinoblastoma protein (pRB) and cell cycle-related proteins, resulting in cell cycle arrest and inhibited cardiomyocyte proliferation. The findings emphasize the importance of monitoring sex hormones during pregnancy and tracking cardiac function in offspring at risk of intrauterine androgen exposure.
April 2020 in “The FASEB Journal” Loss of Rap1 protein speeds up heart aging in mice.
January 2023 in “ALEXMED ePosters (Online)” Alopecia patients have a higher risk of heart disease.
May 2023 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” High doses of rosemary extract can harm the liver, kidneys, and reproductive organs in young rats.
January 2015 in “Indian Journal of Medical Biochemistry” Men with early balding should be checked for metabolic syndrome, as there's a link between the two.