The user plans to switch from topical to oral finasteride (1mg/day) and minoxidil (3mg/day) due to unsatisfactory results with topical treatments. They seek advice on the effectiveness, potential side effects, and the timing for considering a hair transplant, with recommendations to monitor health metrics like blood pressure and conduct thorough bloodwork before starting.
MCL-1 protein may help maintain hair follicles in the growth phase and prevent miniaturization. There is interest in experimental treatments like exosomes, peptides, or stem cell serums to upregulate MCL-1 for hair loss, especially for those not using minoxidil or finasteride.
Fatty acid metabolic signaling can activate epithelial stem cells for hair regeneration. Oleic and palmitoleic acids showed the best results, but practical application on humans remains uncertain.
PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.