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Did you mean Cell Cycle Arrest?

GlossaryCell Cycle Arrest

process that halts cell division to repair damage or stress

Cell cycle arrest is a mechanism that stops the progression of the cell cycle, preventing cells from dividing. This can occur in response to DNA damage, lack of nutrients, or other stress signals, allowing the cell time to repair itself or, if the damage is too severe, to initiate programmed cell death (apoptosis). This process is crucial for maintaining genetic stability and preventing the proliferation of damaged cells, which can lead to diseases like cancer.

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Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

research Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death

January 2022 in “International Journal of Medical Sciences”

Cedrol may be an effective treatment for colorectal cancer.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

Optimizing Scalp Cooling: Structural Follicular Characteristics and Restorative Advances

research Optimizing Scalp Cooling: (Ultra)Structural Follicular Characteristic and Restorative Advances

June 2025 in “Cancer Management and Research”

Improving hair health and managing conditions can enhance scalp cooling effectiveness in preventing hair loss during chemotherapy.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

25 citations , September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

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community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 9 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community TDM-105795 phase 2 results are in!

in Research/Science 28 upvotes 2 years ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 94 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community True hair loss Vs shedding cycle

in Finasteride/Dutasteride 2 upvotes 5 months ago

The user stabilized hair loss with oral finasteride, dutasteride, and topical minoxidil, and underwent a stem cell and PRP procedure. Recent increased hair shedding may be due to restarting dermarolling, affecting minoxidil absorption, or the waning effects of the stem cell treatment.

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