Search

for
Search:

Did you mean Cell Cycle Arrest?

GlossaryCell Cycle Arrest

process that halts cell division to repair damage or stress

Cell cycle arrest is a mechanism that stops the progression of the cell cycle, preventing cells from dividing. This can occur in response to DNA damage, lack of nutrients, or other stress signals, allowing the cell time to repair itself or, if the damage is too severe, to initiate programmed cell death (apoptosis). This process is crucial for maintaining genetic stability and preventing the proliferation of damaged cells, which can lead to diseases like cancer.

Related Terms

Sort by

Research

30 / 1000+ results

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

research Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death

January 2022 in “International Journal of Medical Sciences”

Cedrol may be an effective treatment for colorectal cancer.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

Optimizing Scalp Cooling: Structural Follicular Characteristics and Restorative Advances

research Optimizing Scalp Cooling: (Ultra)Structural Follicular Characteristic and Restorative Advances

June 2025 in “Cancer Management and Research”

Improving hair health and managing conditions can enhance scalp cooling effectiveness in preventing hair loss during chemotherapy.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

25 citations , September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

research Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

30 citations , December 2021 in “Frontiers in Microbiology”

Cepharanthine effectively reduces Herpes Simplex Virus Type 1 by blocking certain cell pathways and promoting cell death.

research N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth

15 citations , April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

A3B5 can reduce skin pigmentation and slow melanoma growth.

research Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

68 citations , January 2013 in “BMC Pharmacology and Toxicology”

Glibenclamide slows breast cancer cell growth by stopping cell division.

research 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis

18 citations , December 2016 in “European journal of pharmacology”

A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.

research Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

48 citations , April 2023 in “Aging Cell”

Targeting cellular senescence may improve skin aging and disorders.

research Study of alpha mangostin as a chemoprotective agent for breast cancer via activation of the p53 pathway

1 citations , January 2019 in “Digital Commons @ Olivet (Olivet Nazarene University)”

Alpha mangostin may protect certain breast cancer cells by activating the p53 pathway.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

XMU-MP-1 Induces Growth Arrest in a Model Human Mini-Organ and Antagonizes Cell Cycle-Dependent Paclitaxel Cytotoxicity

research XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

4 citations , September 2020 in “Cell division”

XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures

61 citations , September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

research Cell Cycle Regulation and Regeneration

27 citations , January 2012 in “Current Topics in Microbiology and Immunology”

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research HAIR MATRIX CELL KINETICS: A SELECTIVE REVIEW

20 citations , September 1978 in “International Journal of Dermatology”

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

research Formononetin: A Pathway to Protect Neurons

35 citations , July 2022 in “Frontiers in Integrative Neuroscience”

Formononetin may help protect the brain and treat neurological diseases.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

research Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

59 citations , April 2016 in “Breast Cancer Research and Treatment”

Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.

Molecular Functional Analyses Revealed Essential Roles of HSP90 and Lamin A/C in Growth, Migration, and Self-Aggregation of Dermal Papilla Cells

research Molecular functional analyses revealed essential roles of HSP90 and lamin A/C in growth, migration, and self-aggregation of dermal papilla cells

10 citations , May 2018 in “Cell death discovery”

HSP90 and lamin A/C are crucial for hair growth and could be targets for treating hair loss.

research Madarosis

33 citations , November 2006 in “Survey of Ophthalmology”

Madarosis is the loss of eyelashes and eyebrows due to various health issues and requires thorough examination to diagnose and treat the underlying cause.

research Mild oxidative stress protects against chemotherapy-induced hair loss

2 citations , January 2023 in “Frontiers in Oncology”

Mild oxidative stress can prevent hair loss from chemotherapy.

research Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

9 citations , November 2013 in “BMC Pharmacology and Toxicology”

Suppressing eIF4E can prevent hair loss from chemotherapy.

research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells

39 citations , August 2022 in “Pharmaceutics”

Combining letrozole and quercetin in spanlastics may improve breast cancer treatment.

research Lysocellin, a metabolite of the novel drug ‘alopestatin’, induces G1 arrest and prevents cytotoxicity induced by etoposide

1 citations , April 2006 in “International Journal of Oncology”

Lysocellin helps stop cell damage from etoposide and may prevent hair loss.

research VDR is an essential regulator of hair follicle regression through the progression of cell death

1 citations , September 2023 in “Life science alliance”

Vitamin D Receptor is crucial for hair follicle shrinkage and cell death, affecting hair growth.