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GlossaryCell Reprogramming

process of converting specialized cells into stem cell-like states

Cell Reprogramming, also known as Cellular Reprogramming, is a process where specialized cells, such as skin cells, are converted back into a more primitive, stem cell-like state. This is typically achieved by introducing specific genes or proteins that reset the cell's identity, allowing it to potentially develop into different types of cells. This technique holds significant promise for regenerative medicine, including treatments for conditions like alopecia, where new hair follicles could be generated from reprogrammed cells.

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Research

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research Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice

14 citations , February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Regulation of somatic cell reprogramming through inducible mir-302 expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

research Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule

January 2025 in “Biochemical Pharmacology”

Peficitinib can turn human fibroblasts into cells that help grow hair.

research Hypoxia in Cell Reprogramming and the Epigenetic Regulations

36 citations , January 2021 in “Frontiers in Cell and Developmental Biology”

Hypoxia and epigenetics are crucial for cell growth and tissue regeneration.

research Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea

16 citations , February 2022 in “Science Advances”

Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.

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Community Join

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Hair Multiplication Projects in China - Promising clinical trial results on Mice

in Technology 35 upvotes 1 year ago

A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

in Research/Science 133 upvotes 1 year ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community Do you believe there will be a game changing treatment in the next 10 years?

in Chat 67 upvotes 4 years ago

Users discuss potential game-changing hair loss treatments in the next 10 years. Some mention KX-826, SCUBE3, and stem cells as promising options, while others express doubt due to past disappointments and lack of focused research.

community The mechanism of androgenic alopecia

in Research/Science 34 upvotes 10 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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Learn

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learn Stem Cell Factor

learn Apple stem cell

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