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research The role of tight junctions in skin barrier function and dermal absorption

156 citations , August 2016 in “Journal of controlled release”

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

research A study of the effects of physical dermabrasion combined with chemical peeling in porcine skin

5 citations , October 2014 in “Journal of cosmetic and laser therapy”

Combining physical dermabrasion with chemical peeling is more effective for skin treatment than chemical peeling alone.

research Hair removal and bioavailability of chemicals: Effect of physicochemical properties of drugs and surfactants on skin permeation ex vivo

10 citations , June 2019 in “International Journal of Pharmaceutics”

Hair removal methods damage the skin barrier and affect substance penetration.

research Cutaneous Drug Delivery: An Update

25 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

New methods like nanoparticles and microneedles show promise for better skin drug delivery, especially for hair disorders.

research Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure

9 citations , January 2023 in “Langmuir”

Solubility in skin changes with hydration, affecting chemical absorption.

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community Does anyone know the chemical formula for pelage pp405?

in Research/Science 14 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

in Finasteride/Dutasteride 286 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

in Research/Science 48 upvotes 6 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Does RU58841 potentially cause cancer?

in Research/Science 1 year ago

RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.

community Genuine Minoxidil Sanity Check-Tiktok Shops

in Minoxidil 187 upvotes 1 year ago

A user bought Kirkland Minoxidil from a TikTok shop and sought confirmation of its authenticity through a bleach test, which some users warned could be dangerous. Many participants advised against buying from TikTok due to the risk of fakes, suggesting alternatives like buying from Costco or reputable online pharmacies.

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