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5 / 57 resultsresearch Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer
A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.
research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
This study investigates the role of the enzyme PADI4 in hair follicle development, highlighting its function as a negative regulator of progenitor cell proliferation. PADI4, which converts peptidylarginine to citrulline, is found in both progenitor and differentiated hair lineage cells and represses transcription during hair follicle development. The enzyme citrullinates proteins involved in mRNA processing and ribosomal biogenesis, and its absence enhances protein synthesis and ribosomal RNA transcription. Additionally, PADI4 modifies the translational repressor 4E-BP1, indicating a regulatory interaction between PADI4 activity and 4E-BP1 phosphorylation. This research provides insights into how posttranslational modifications influence progenitor cell states and tissue formation.
research Citrullination at the Inflammatory Skin Barrier
A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.
research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles
Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.
research Ca 2+ -mediated protein citrullination regulates proliferation in the regenerating and malignant CNS
Ca²⁺-mediated protein citrullination controls cell growth in the CNS and may help treat brain tumors.
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5 / 1000+ resultscommunity Can amino acids help with AGA
Amino acids like lysine, methionine, and cysteine may help with androgenetic alopecia when taken in high doses along with a DHT blocker. Users discuss combining these with treatments like Minoxidil, finasteride, and RU58841.
community topical cetirizine to control scalp inflammation
The user applies a topical solution containing minoxidil, finasteride, dutasteride, retinoic acid, and hydrocortisone to address scalp inflammation and is considering adding cetirizine to the mix. They are calculating the correct amount of cetirizine to add to their formula and have paused this approach to retry oral minoxidil.
community A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia.
The conversation discusses using topical cetirizine as a treatment for androgenetic alopecia (hair loss). Specific treatments mentioned include Minoxidil, finasteride, and RU58841.
community 1% cetirizine (available in allergy medicines) for androgenetic alopecia
The conversation discusses using 1% cetirizine, an antihistamine, as a potential treatment for androgenetic alopecia (hair loss). One user plans to try cetirizine instead of finasteride, while others are curious or skeptical about its effectiveness, discussing the role of inflammation in hair loss.
community Glycine supplementaion is said to strongly upregulate 5-alpha Reductase (5-ar) Activity
Glycine supplementation may increase 5-alpha reductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.