research Sex Differences in Physiological Hair Cycling and Adhesive Material-Induced Hair Regeneration in Mice
The study investigates sex differences in hair cycling and adhesive material-induced hair regeneration in male and female C3H/He mice. It was found that males entered the second and third anagen phases earlier than females, suggesting longer telogen phases in females. However, females showed earlier localized hair regrowth after the application and removal of a cyanoacrylate adhesive material. Ovariectomy led to a widespread telogen-to-anagen transition, complicating the isolation of ovarian hormone effects. RNA sequencing revealed sex-dependent baseline expression profiles related to inflammation and tissue repair. Clodronate liposome treatment delayed hair growth and wound healing in males but had less impact on females, indicating a more macrophage-dependent regenerative response in males. These findings highlight distinct sex differences in physiological hair cycling and regenerative responses.
