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GlossaryAndrogen Deficiency

insufficient production of male hormones, primarily testosterone

Androgen Deficiency, also known as Testosterone Deficiency or Hypoandrogenism, refers to a condition where the body produces insufficient levels of androgens, primarily testosterone. This can lead to symptoms such as reduced libido, fatigue, depression, and loss of muscle mass in men, and can also affect women, though less commonly. It can result from various causes, including aging, medical conditions, or certain medications.

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community Kintor Pharmaceutical Announced U.S. FDA Has Greenlighted Phase II Clinical Trial for Pyrilutamide to Treat Androgenetic Alopecia

in Treatment 26 upvotes 4 years ago

Chinese company gets green light for Pyrilutamide Phase II trial for androgenetic alopecia. Androgen receptors downregulate in androgen deficient environments.

community Vitamin D deficiency hair loss

in Chat 10 upvotes 2 years ago

A 20-year-old male has been experiencing hair loss for three years due to a vitamin D deficiency and has seen no improvement after 3.5 months of taking supplements. Another person suggested that if the hair loss follows a pattern, it might be regular baldness rather than due to the deficiency.

community Severe copper deficiency, and also zinc deficiency. Looking for testimonials.

in Research/Science 2 upvotes 5 months ago

A 36-year-old man with androgenetic alopecia suspects copper and zinc deficiencies may be accelerating hair loss and is supplementing copper to address this. He is also monitoring blood sugar levels due to previous prediabetes concerns and plans to test for insulin resistance.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Does vitamin D deficiency actually cause hair loss? Has anyone actually grew back hair after fixing vitamin d levels?

in Chat 65 upvotes 1 year ago

Vitamin D deficiency can contribute to hair loss, but it is not the sole cause, and supplementation may not always resolve the issue. Treatments like finasteride and minoxidil are recommended for hair regrowth, with vitamin D and other supplements providing additional support.

community Why do people downplay vitamin deficiency when 94% of Americans are vitamin D deficient?

in Research/Science 126 upvotes 2 years ago

The conversation is about the role of vitamin deficiencies in hair loss and the effectiveness of treatments like Minoxidil, finasteride, and RU58841. It concludes that while vitamins and nutrition are important, they are not the primary solution for androgenic alopecia.

community I'm on multiple anti-androgens and after around year, my hairs are thinner, why?

in Finasteride/Dutasteride 16 upvotes 2 years ago

The user has been using finasteride, dutasteride, pyrithione zinc, and oral minoxidil to treat hair loss and has seen an increase in fine hairs on the hairline but overall thinning on the top. They are considering adding zinc and Vitamin K to their regimen and are already taking hair multivitamins with collagen.

community 26F Thinner hair due to vitamin deficiencies?

in Female 12 upvotes 2 years ago

A female user with chronic anemia and vitamin deficiencies is experiencing finer, straighter hair and seeks recommendations for scalp products to improve circulation and prevent potential hair thinning. She is considering growth oils but is unsure of their effectiveness.

community If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit?

in Finasteride/Dutasteride 13 upvotes 4 years ago

The conversation discusses the effectiveness of reducing DHT for hair loss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.

community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.

in Chat 8 upvotes 3 years ago

The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 197 upvotes 10 months ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

in Research/Science 39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community On a super stack, but still miniaturizationg going strong???

in Update 9 upvotes 3 years ago

User "Number_Worried00" is using a treatment stack for hair loss, including Minoxidil, Finasteride, Dutasteride, Estradiol, Cetirizine, and Pyrilutamide. Another user suggests that if the cause is vitamin deficiency or inflammation, the stack may not be effective.

community Hair regrow idea: High dose Testosterone + RU58841

in Satire 2 upvotes 1 week ago

Using high doses of testosterone with RU58841 to create an androgen-free environment for hair regrowth is suggested, but concerns about heart health and the effectiveness of this approach are raised. Alternatives like topical estrogen, progesterone, and other treatments like finasteride and dutasteride are discussed.

community Has anyone used zinc as a treatment?

in Treatment 25 upvotes 1 year ago

Zinc is not effective for hair loss unless there's a deficiency. Finasteride and minoxidil are recommended treatments.

community My Experience and a Discourse on "DUPA"

in Treatment 9 upvotes 1 year ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

community 1 and a half years on fin - hair is way worse.

in Finasteride/Dutasteride 9 upvotes 3 years ago

The user reported worsening hair loss after 1.5 years on finasteride, questioning if chronic iron deficiency could be a cause. They noted no side effects from finasteride.

community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

in Treatment 9 upvotes 8 months ago

OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

community Breezula phase 3 results said to be released next month

in Product 27 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Thoughts about ORAL ketoconazole? (pills)

in Ketoconazole 3 months ago

Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

community Lost and need help

in General 156 upvotes 1 year ago

A 15-year-old is experiencing hair loss and has tried rosemary and jojoba oils without success. They are advised to see a doctor for thyroid and androgen tests and consider using Minoxidil.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 66 upvotes 1 year ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community do any supplements actually work?

in Female 6 upvotes 2 years ago

A user asked if collagen or hair growth supplements made their hair thicker. Another user suggested that Vitamin D might help if deficient.

community Diffuse thinning fucking sucks

in Update 430 upvotes 2 years ago

The conversation discusses various treatments for hair loss, including finasteride, minoxidil, dutasteride, microneedling, and checking for nutrient deficiencies. Some users suggest adding hydrocortisone butyrate, low-dose progesterone, or tretinoin to treatment regimens, while others recommend cosmetic solutions like Toppik hair fibers or shaving the head.

community Prolonged shedding over last 15 months

in Update 2 upvotes 3 months ago

The user has been experiencing prolonged hair shedding despite using Dutasteride, Minoxidil, and topical Finasteride, with blood tests showing high free testosterone and low SHBG. Suggestions include adjusting Minoxidil dosage, considering topical anti-androgens like RU58841, and addressing metabolic factors to increase SHBG.

community Dutasteride 1.5 years and Oral Minoxidil 1 year progress!

in Is this regrowth? 42 upvotes 9 months ago

A user switched from finasteride to dutasteride and added oral minoxidil for hair loss but saw limited improvement. They are considering increasing doses, trying RU58841, and possibly a hair transplant, while others suggest checking for vitamin deficiencies.

community 21M Started young, treated early, but non-responder to dht blockers

in Finasteride/Dutasteride 58 upvotes 10 months ago

A 21-year-old male uses minoxidil, finasteride, and dutasteride for hair loss but still experiences progression with high DHT levels. Suggestions include increasing dosages, checking for deficiencies, considering a hair system, or consulting a specialist.

community I don’t want to give up but running out of options

in Finasteride/Dutasteride 1 upvotes 1 year ago

The user has been on oral Dutasteride and Minoxidil for 16 months but continues to experience hair miniaturization. They previously used oral Finasteride and topical Minoxidil with success for 7 years and are now seeking advice on whether to switch back to topicals, adjust dosages, or consider other treatments like topical anti-androgens or Estradiol.

community Does low HGH leading to hairloss?

in Research/Science 12 upvotes 2 years ago

The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.