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GlossaryCytocompatibility

ability of a material to safely interact with cells

Cytocompatibility refers to the ability of a material to interact with cells without causing harmful effects. In simpler terms, it's about how well a material can coexist with living cells, which is crucial for medical implants, tissue engineering, and other biomedical applications. For instance, when developing a new scalp treatment for alopecia, ensuring the cytocompatibility of the treatment means it won't damage the hair follicles or surrounding skin cells.

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community Binding affinity does not equal potency for anti androgens? Comparing pyrilutimide to cb-03-01

in Research/Science 7 upvotes 3 years ago

Pyrilutimide and CB-03-01, two treatments for hair loss, have similar clinical trial results despite different binding affinities to androgen receptors. Factors other than binding affinity, like the time a drug stays bound to the receptor, may influence their effectiveness.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community Pyrilutamide binding affinity is similar to RU

in Research/Science 16 upvotes 3 years ago

Comparing the effectiveness of RU58841, Pyrilutamide and CB-03-01 as treatments for hair loss, with people discussing different aspects such as binding affinity, time of inhibition, safety data and cost.

community Concerns about CosmeRNA safety mechanisms

in Treatment 3 upvotes 3 years ago

Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

community Pyrilutamide kintor pharmaceutical

in Chat 6 upvotes 2 years ago

The conversation is about seeking information on GT20029 from Kintor Pharmaceutical as a potential hair loss cure and inquiring about experiences with CosmeaRNA.

community Is anoying mixing pyrilutamide with another compound for full scalp coverage?

in Research/Science 6 upvotes 3 years ago

User uses 1ml RU58841 with 5ml stemoxydine for scalp coverage. Wants to switch to pyrilutamide and asks about mixing it with other compounds.

community Cypro to reverse hairloss + Fin?

in Treatment 1 year ago

The conversation discusses using cyproterone temporarily to reverse hair loss, followed by finasteride to maintain regrowth. Concerns about cyproterone's side effects, such as lowering testosterone and potential health risks, are raised, with alternatives like spironolactone suggested for androgen-related issues.

community Topical Solution Mix: Stemoxydine, RU-58841, Alfatradiol, and Tretinoin - Feasibility and Potential Interactions?

in Chat 5 upvotes 2 years ago

A user is considering mixing Stemoxydine, RU-58841, Alfatradiol, and Tretinoin into a single topical solution for hair loss. They are concerned about potential interactions that could reduce the effectiveness of these ingredients.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 4 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community Pyrilutamide cease and desist from Kintor

in Transplants 12 upvotes 3 years ago

Considering a hair transplant, using Pyrilutamide, the potential availability of CosmeRNA, and the significance of taking Minoxidil and Finasteride for long-term results.

community Ethanol or PEG400 Carrier for RU58841 on Science bio

in Treatment 7 upvotes 4 years ago

The conversation discusses the best carrier for RU58841, comparing Ethanol and PEG400. The user seeks advice on which carrier is more effective.

community Ordered copper peptides - how to apply?

in Treatment 1 upvotes 1 year ago

Gizzela is unsure about the dosage and frequency of copper peptides and asks if they can be used with Stemoxydine. They seek advice on applying these treatments together.

community Pyrilutamide (KX-826) vs CB-03-01 which one do you think is better?

in Product 8 upvotes 3 years ago

The conversation is about comparing hair loss treatments Pyrilutamide (KX-826) and CB-03-01, discussing their cost, side effects, and effectiveness. The user questions whether to try CB-03-01, which is more expensive and potentially less effective, or switch to the cheaper and possibly better Pyrilutamide.

community C60 + microneedling – on off days from Pyrilutimide

in Microneedling 1 upvotes 3 years ago

User discusses using C60 serum with microneedling at 1.75mm and asks if it's safe. Current routine includes daily Pyril on temples, weekly microneedling, and C60 serum on non-Pyril days.

community Hives/Rash from Kx 826 Pyrilutamide???

in Chat 1 upvotes 1 year ago

OP developed hives after using Kx 826 (Pyrilutamide) 1% twice daily for 3 weeks. The hives appeared on the arms, chest, and groin area.

community No side effects on pyrilutamide / KX-826 so far

in Research/Science 207 upvotes 4 years ago

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community fluridil (topilutamide) vs. cb-03-01 (clascoterone)

in Research/Science 5 upvotes 2 years ago

The conversation is about comparing the effectiveness of fluridil and clascoterone in preventing hair loss and inquiring about their use as standalone treatments. There is a question about the concentration of the fluridil brand for efficacy.

community How cyproterone acetate and spironolactone come to my mind whenever I look in the mirror

in Satire 11 upvotes 7 months ago

The conversation humorously discusses hair loss treatments, mentioning spironolactone and cyproterone acetate. It reflects a sense of frustration and satire about the effectiveness of these treatments.

community I just started a topical cetirizine treatment.

in Treatment 8 upvotes 2 years ago

The conversation is about using topical cetirizine for hair loss treatment. The user mixes Aller-TEC tablets with a hair tonic but faces issues with the solution's consistency.

community Is stemoxydine (serioxyl advanced) toxic/lethal to cats?

in Chat 1 upvotes 1 year ago

The conversation is about concerns regarding the safety of using stemoxydine (Serioxyl Advanced) around cats, with the user also using minoxidil, oral minoxidil, dutasteride, and microneedling for hair loss. The user is seeking advice on whether stemoxydine is toxic or lethal to cats.

community Did someone make his own Xyon Gel liposomal with Pyrilutamide ?

in Research/Science 5 upvotes 3 years ago

Creating a liposomal gel with Pyrilutamide for hair loss to reduce systemic effects, similar to Xyon's gel. The discussion includes concerns about ingredient sourcing and the benefits of targeted topical treatments.

community Homemade pyri solution- problems

in Treatment 1 upvotes 2 years ago

A user mixed a pyrilutamide solution and noticed undissolved powder at the bottom, questioning if this is normal and how long to wait before applying it. They wished others good luck with their treatments.

community People who used cyproterone for hair loss

in Treatment 2 upvotes 2 years ago

The conversation discusses the use of 12.5mg cyproterone every other day for hair loss. There's a concern about reducing testosterone potentially increasing DHT and negatively affecting hair.

community Pyrilutamide / KX-826 | Discussion EU

in Research/Science 4 upvotes 2 years ago

The conversation is about a user expressing concerns over the safety of a new drug called Pyrilutamide (also known as KX-826) for hair loss. The user will only trust the drug if it's permitted by EU regulations and sold by a reputable company.

community Pyrilutamide solution question

in Research/Science 8 upvotes 3 years ago

The conversation is about the stability of pyrilutamide in different solutions. The user is asking if a 70/30 ethanol/pg solution with 4% water will degrade pyrilutamide.

community What has the evidence been on side effects with CB?

in Research/Science 4 upvotes 5 years ago

Clascoterone (CB) shows an excellent safety profile with no serious side effects, but its effectiveness may decline after six months, making it more suitable as an adjunct treatment with finasteride and minoxidil rather than a standalone solution. Some argue it could be better than finasteride due to its protection against testosterone, but its long-term efficacy remains debated.

community Mixing stemoxydine and pre mixed ru58841

in Product 7 upvotes 4 years ago

User asks if mixing RU58841 solution with Serioxyl is okay for better scalp coverage and worries about reduced effects.

community cb-03-01 research chem (winlevi/clascoterone cream)

in Technology 3 upvotes 2 years ago

The user is considering using CB or clascoterone for hair loss, potentially as an alternative to RU. They're also contemplating asking a dermatologist for topical clascoterone cream to apply to their temple.

community What do you think about this galenic lotion by my trichologist?

in Hair Systems 2 upvotes 1 year ago

The user discusses a galenic hair lotion containing progesterone, estradiol, cyproterone, hydrocortisone butyrate, and cetirizine pheniramine, which has effectively stopped their hair loss over two years. They are curious about the compatibility of finasteride with the lotion's components and note that their trichologist has successfully used minoxidil and finasteride in similar treatments for others.