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Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

Significant hair regrowth was achieved using EssenGen 6-Plus with 6% minoxidil and 0.05% finasteride, along with Nizoral shampoo, over 12 weeks. No side effects were experienced, highlighting the benefits of a low dose.

Parasites in the gut may contribute to hair loss by depleting essential nutrients and disrupting hormone balance. An imbalance of hormones, not just DHT, could be a factor in androgenic alopecia.

Minoxidil and finasteride work through different mechanisms; minoxidil-dependent hair requires continued use to maintain growth, while finasteride prevents further hair loss but cannot sustain minoxidil gains alone. Current treatments like minoxidil, finasteride, and others need indefinite use, as no permanent solution exists yet.

The user is considering trying finasteride again for hair loss despite past side effects like tender nipples and concerns about mental health impacts. They are advised to consult a doctor and consider topical or low-dose finasteride.

The conversation discusses hair regrowth progress using 1mg oral finasteride and 5mg oral minoxidil daily over three years. Concerns about potential heart risks from minoxidil dosage are raised, with suggestions to consult a doctor and consider reducing the dose.

A hair transplant without using finasteride or similar medications may lead to unnatural results and further hair loss. Financially capable individuals are advised to stabilize hair loss with medication before considering a transplant.

A user underwent a hair transplant at Moart Clinic in Seoul, receiving 1100 grafts in the crown area after Dutasteride and oral Minoxidil failed to improve a stubborn bald spot. The procedure was successful, with minimal pain and good post-op recovery, costing $6900 USD before a tax refund.

Clascoterone (Breezula) shows a potential 500% increase in hair growth, possibly outperforming minoxidil and finasteride. It is in advanced trials, with hopes for FDA approval, but cost and side effects are concerns.

A 25-year-old male with 10 years of hair loss is using minoxidil and considering adding finasteride or dutasteride, possibly with microneedling, to improve hair regrowth before a hair transplant. Community members suggest starting a DHT blocker immediately, considering oral minoxidil, and addressing low vitamin D and HDL levels.

A 19-year-old male is experiencing hair loss and has been prescribed finasteride by a Telehealth company. He plans to start finasteride, improve his lifestyle, and take supplements like DIM and Zinc to manage potential side effects.

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

The conversation is about hair regrowth and treatments for hair loss, specifically discussing the use of minoxidil, dermarolling, and finasteride. Users suggest starting finasteride to prevent further hair loss and potentially regrow thicker hair, while some express concerns about its effects on sperm count.

Topical dutasteride with microneedling is effective for androgenetic alopecia, improving hair thickness and density. Further research is needed to confirm long-term efficacy.

Creatine does not cause or worsen hair loss, despite some anecdotal reports of hair thinning. The discussion emphasizes that these reports are not supported by scientific evidence.

The user switched from finasteride to dutasteride and oral minoxidil after experiencing side effects and worsening hair loss, which improved their condition. Dutasteride was preferred due to fewer side effects and better results compared to finasteride.

The conversation humorously discusses the effects of finasteride on sexual orientation and hair improvement, with users joking about its potential to change attraction. It also mentions other treatments like dutasteride and minoxidil, with some users sharing their experiences and side effects.

A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

The conversation humorously discusses hair loss treatments, mentioning scalp massage, minoxidil, and the ineffectiveness of devices like the "Gr0wBand." It highlights the role of androgens in hair loss and suggests that increased blood flow from massage may not significantly impact hair growth.

The user experienced significant hair regrowth using 1mg oral finasteride, DIM, and beetroot powder, while also focusing on gut health and reducing alcohol intake. Other users discussed the importance of iodine, fermented foods, and maintaining a balanced diet for overall health and hair improvement.

The conversation is about purchasing dutasteride solution for mesotherapy, with a suggestion to make it using dutasteride capsules and oils. A user shared a link to a potential supplier and mentioned using dutasteride with microneedling.

The user has been using topical 5% minoxidil for six months with minimal results and is worried about greasy hair and potential side effects of adding finasteride. Others suggest combining minoxidil with finasteride for better results, while discussing potential side effects like erectile dysfunction.

A user experienced hairline improvement after four weeks on 1.5mg dutasteride but had side effects like reduced libido and sensitive nipples. They plan to switch to finasteride to manage these side effects.

Dutasteride can regrow hair lost up to 10 years ago for some, especially when combined with minoxidil, but results vary widely. Some users report significant regrowth, while others see no change or only maintain existing hair.

A female experienced hair loss due to low iron and an undiagnosed thyroid issue, specifically Hashimoto's, and saw improvement after starting thyroid medication, iron supplements, and making lifestyle changes. She emphasizes the importance of addressing the root cause and shares her journey to regrowth and emotional recovery.

A 19-year-old transgender individual is experiencing worsening temple recession despite taking female hormones and 1.25mg finasteride. They are seeking advice on additional treatments to address hair loss.

The user has been using finasteride, dutasteride, and minoxidil without success and is considering a comprehensive blood test to explore other causes of hair loss. They are unsure about the necessity and cost of the extensive tests and are seeking advice on whether to proceed with the full panel or focus on specific tests.

A 31-year-old experienced significant hair loss reduction using oral finasteride for 4 months, after trying various treatments like oils, shampoos, and saw palmetto. The user avoided minoxidil due to its inconvenience and potential side effects, finding finasteride alone effective for their needs.

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.