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    GlossaryGap Junctions

    Gap junctions are specialized intercellular connections that allow for direct communication between adjacent cells through the exchange of ions and small molecules. In the context of hair biology, they play a crucial role in maintaining the homeostasis of hair follicle cells and facilitating the signaling necessary for hair growth and cycling. Key distinguishing characteristics of gap junctions include their formation by connexin proteins, which assemble to create channels that bridge the cytoplasmic space between cells, enabling coordinated cellular responses that are vital for healthy hair follicle function. Disruption of gap junction communication can contribute to hair loss and other hair disorders.

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      community Min/Fin/Needle July 2024-March 2026

      in Progress Pictures  32 upvotes 1 month ago
      The user experienced hair regrowth and improved hair density using oral finasteride and topical minoxidil, with microneedling as an additional treatment. They are considering a hair transplant for low-density areas but are uncertain due to existing follicles.

      community Conversations about hair-loss with normies: They're always funny.

      in Chat  12 upvotes 5 years ago
      Hair loss is often misunderstood by those not affected, leading to frustration for those who research treatments like Minoxidil, finasteride, and hair transplants. Many people offer well-meaning but uninformed advice, while those knowledgeable about hair loss focus on proven treatments.

      community risks with finasteride and dutasteride

      in Research/Science  142 upvotes 9 months ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

      community What was your “f*ck I’m balding” story?

      in Chat  178 upvotes 2 years ago
      User noticed thinning hair at 18-19, started finasteride at 22 and minoxidil at 24, with positive results. Others shared hair loss experiences and treatments, including finasteride, minoxidil, and hair transplants.

      community Happiness is just a gap between sheds

      in Progress Pictures  107 upvotes 5 months ago
      A user shared their experience with hair loss treatments, switching from 1mg finasteride and topical minoxidil to 5mg oral minoxidil and oral dutasteride, noting improvements despite shedding phases. Other users discussed the hair growth cycle, treatment effects, and shared advice on managing hair loss, including buzzing hair and maintaining mental health.

      community Running out of finasteride

      in General  43 upvotes 10 months ago
      The user completed their first month using oral finasteride and topical minoxidil without issues but is concerned about a 2-3 day gap in their finasteride supply affecting progress. They are also seeking advice on obtaining a multi-month supply.

      community Adding topical Min and dermastamping to oral Min/Fin?

      in Treatment  1 upvotes 3 months ago
      The user has been using oral Minoxidil, Finasteride, and Biotin for hair recovery and is considering adding topical Minoxidil and dermastamping to improve results. It is suggested to use micro-needling once a week with a 24-hour gap before applying topical Minoxidil.

      community Taking fin for 2 years, should I swap to dut?

      in General  98 upvotes 6 months ago
      The user has been using finasteride inconsistently for 2 years and minoxidil for 6 months without seeing hair growth. They are considering switching to dutasteride and restarting minoxidil to address thinning at the right temple, with advice suggesting consistent use for better results.

      community How often to microneedle for optimal results

      in Microneedling  10 upvotes 1 year ago
      Microneedling for hair loss is discussed, with users suggesting different frequencies and needle lengths, such as 1.5mm every 3 to 6 weeks or 1.0mm weekly. Some users recommend less frequent sessions to avoid scalp damage and soreness.

      community 1mg Finasteride and 2.5mg minoxidil. (2 months)

      in Progress Pictures  192 upvotes 2 years ago
      A user started treating their hair loss with 1mg finasteride and 2.5mg minoxidil daily, and has seen progress in two months. They also use 2% ketoconazole shampoo twice a week and a derma stamp once a week with liquid minoxidil.

      community The Breezula 539% headline is doing a lot of heavy lifting right now.

      in Research/Science  14 upvotes 5 days ago
      Breezula shows promising results for hair loss, with one trial showing a 539% improvement and another 168%, but lacks combination data with treatments like minoxidil or dutasteride. Its mechanism differs from finasteride, potentially offering fewer side effects by blocking receptors locally at the follicle.

      community Switching to oral minoxidil...

      in Minoxidil  3 upvotes 1 week ago
      OP plans to switch from topical to oral minoxidil due to limited results and is advised to overlap both for a few weeks before discontinuing the topical. Oral minoxidil may be more effective for non-responders to topical treatment.

      community my daily breakfast til the day i die

      in Satire  662 upvotes 1 month ago
      Using both finasteride and dutasteride for hair loss is debated, with some seeing it as beneficial during transition, while others find it redundant and risky. Oral minoxidil raises concerns about blood pressure, with a preference for topical use and microneedling for better results.

      community Breezula Phase 3 confusion - did they change something?

      in Chat  8 upvotes 3 months ago
      Breezula's phase 2 showed reduced efficacy after 6 months, but phase 3 had positive results, causing confusion about any changes made to the drug. There is frustration over the long timeline for hair loss treatments, with some users expressing more interest in other potential treatments like GT-20029.

      community Ok keep it real, is Fin not for me? Tried it 10 years ago

      in General  172 upvotes 4 months ago
      The user is considering trying finasteride again for hair loss despite past side effects like tender nipples and concerns about mental health impacts. They are advised to consult a doctor and consider topical or low-dose finasteride.

      community Haïr différence after 1 year dut with alternate days

      in Finasteride/Dutasteride  63 upvotes 5 months ago
      The user experienced hair thickening and regrowth using dutasteride on alternate days, oral minoxidil every third day, and daily hair massages, but is dealing with dandruff and inflammation. They are considering adjusting their minoxidil dosage and have started using ketoconazole shampoo and cupping therapy for additional benefits.

      community Microneedling + topical fin/min: how to structure the routine?

      in General  78 upvotes 7 months ago
      The user is using a topical spray containing finasteride, minoxidil, ketoconazole, and biotin for hair loss and plans to add weekly dermastamping, starting with a needle length of 0.6mm. They seek advice on the safety of combining these treatments, the impact of skipping one dose weekly, and the frequency of replacing the dermastamp.

      community 2nd HT FOR CROWN AND MID SCALP.

      in Transplants  2 upvotes 7 months ago
      The user underwent a second hair transplant for the crown and mid-scalp, achieving good density. They are using minoxidil, finasteride, and biotin, and considering PRP treatments to enhance growth.

      community Min, without fin. Worth it or no

      in Minoxidil  104 upvotes 11 months ago
      Minoxidil can be used alone to address thinning hair, but it may be less effective without finasteride. Minoxidil increases blood flow and may regrow some hair, but it doesn't block DHT.

      community Switching from finasteride to dutasteride.

      in Finasteride  76 upvotes 11 months ago
      The user has been taking finasteride for nearly 5 years and is now adding dutasteride to their regimen to maintain hair loss prevention. They seek advice on transitioning from finasteride to dutasteride.

      community 8 months apart - got all my hair back.

      in Update  4801 upvotes 1 year ago
      A user successfully regrew their hair over 8 months using topical minoxidil, finasteride, a healthy lifestyle, and derma stamping. They emphasize the results are genuine and not from hair transplants.