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GlossaryU2HR protein

truncated protein inhibiting hair growth gene, affecting follicles

The U2HR protein is a truncated form of the U2HR (U2 Hairless Repressor) gene product, which plays a role in hair growth regulation. It acts as an inhibitor of the hairless (HR) gene, which is crucial for hair follicle cycling and maintenance. By interfering with the HR gene's function, the U2HR protein can potentially lead to conditions like alopecia, where hair growth is disrupted.

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community Does whey protein and creatine aggravate hair loss?

in Research/Science 83 upvotes 2 years ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community What regimen do I need to get this hairline?

in Satire 362 upvotes 3 years ago

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

community + 5 years Finasteride and dermarroll journey PICS and ACTUAL DILEMMA

in Progress Pictures 54 upvotes 2 years ago

The user experienced improved hair density and thickness after using finasteride and dermarolling for 2.5 years but noticed hair loss when doing anaerobic exercise. They increased their finasteride dose and continued dermarolling but are considering not starting minoxidil due to its perceived hassle and uncertain long-term benefits.

community 4 months, only Minoxidil 5% ,dermarolling twice a week. hair growth results. any suggestions?

in Minoxidil 461 upvotes 1 year ago

Significant hair growth was achieved using Minoxidil 5% and dermarolling twice a week, with suggestions to add finasteride for maintenance. There is debate on when to apply Minoxidil after dermarolling to avoid irritation.

community 1 year 1 month 1mg finasteride 2.5mg oral minoxidil (eyebrow + scalp gains)

in Progress Pictures 178 upvotes 1 year ago

The conversation is about a user's positive experience with hair regrowth using 1mg finasteride and 2.5mg oral minoxidil, noting improvements in scalp and eyebrow hair. The user mentions minimal side effects, such as a slight increase in heart rate, and prefers oral minoxidil over topical due to ease of use.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Creatine's effect on Hair Loss and DHT

in Research/Science 101 upvotes 2 years ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community (Almost) 3 months on fin+min & microneedle.

in Progress Pictures 1326 upvotes 2 years ago

The user has been using 1mg finasteride every other day, 5% minoxidil daily, and microneedling every two weeks for three months to treat hair loss. They are happy with the progress and considering adding ketoconazole shampoo to their routine.

community This tells you if you're shedding or losing hair (along with other things like fibrosis)

in Research/Science 32 upvotes 1 year ago

High frequency ultrasonography and HR-MRI can help identify hair shedding causes like inflammation and fibrosis. The conversation discusses the potential of using these technologies to evaluate treatments like Verteporfin for hair regeneration.

community Have some questions about prescription I got from a trichologist

in Chat 1 upvotes 1 year ago

A trichologist prescribed Biotrade Sebomax HR Anti-Hair Loss Tonic, Spectral DNC-N Nanoxidil, Hairfollic Him/Man Vitamins, and Bosley MD DHT blocking supplements instead of finasteride due to potential risks at age 21. The user questions the legitimacy of the treatment and considers seeking a second opinion.

community How to know if fin not working?

in Chat 9 upvotes 2 months ago

Finasteride may take 8-12 months to show results, with initial shedding common. Users suggest waiting before considering stronger treatments like dutasteride.

community Even if the new drugs succeed, how are we gonna apply so many topicals?

in Research/Science 13 upvotes 1 month ago

New hair loss treatments like GT20029, Clascoterone, and PP405 are being discussed, with concerns about how to apply multiple topicals alongside existing treatments like minoxidil and finasteride. Suggestions include creating a routine, mixing treatments, or minimizing redundancy in treatment stacks.

community Topical minoxidil responder tests + switching to oral

in Minoxidil 1 upvotes 5 months ago

The user has been using topical minoxidil with tretinoin for 9 months without much regrowth and suspects finasteride is responsible for any improvement. They are inquiring about tests to determine response to topical minoxidil and seeking advice on switching to oral minoxidil, including potential side effects and monitoring requirements.

community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

in Chat 1 upvotes 1 year ago

The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.

community Hair progress over 7 years (Oral fin 1mg + oral min 2.5mg + topical min 5% + micro-needling)

in Progress Pictures 194 upvotes 2 years ago

The user shared a 7-year hair progress journey, starting with occasional minoxidil use and later including a finasteride prescription, online prescriptions, and microneedling. Significant hair growth was achieved, but side effects led to a reduction in medication dosage.

community Has any data on systemic absorption of pyrilutamide been published?

in Research/Science 1 upvotes 1 month ago

Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.

community My crown before and after 12 months of 1.25mg finasteride every day. Taken after shower under the same light

in Progress Pictures 54 upvotes 1 month ago

A 23-year-old user shared progress pictures after 12 months of using 1.25mg finasteride daily, reporting reduced hair shedding and considering adding 2.5mg oral minoxidil for further improvement. The discussion includes potential side effects of oral minoxidil, with users advising caution and monitoring under medical supervision.

community Honestly, happy that asian derms seem to be a lot more open to prescribe fin

in Satire 261 upvotes 1 month ago

Asian dermatologists are more open to prescribing finasteride, while in some regions, medications like finasteride and minoxidil can be obtained without a prescription. In Europe, particularly France, there are stricter regulations requiring patients to acknowledge potential side effects, but many people find ways to obtain these treatments through various means.

community No result even after 4 month of finasteride

in Finasteride/Dutasteride 2 upvotes 2 months ago

OP is using finasteride and minoxidil for hair loss but hasn't seen results after four months. Users advise that noticeable results typically take a year or more, and suggest daily dosing for effectiveness.

community My 3 month 'progress' so far. I feel like it's working.

in Progress Pictures 9 upvotes 5 months ago

The user is experiencing positive hair growth after 3 months using 0.5mg dutasteride, 2.5mg oral minoxidil, topical minoxidil, dermastamping, and biotin shampoo, with some side effects like reduced libido and palpitations. They plan to continue treatment for a year before considering a hair transplant, as advised by another user who suggests waiting for full results from minoxidil and finasteride.

community Oral minoxidil — is it actually worth it?

in Minoxidil 42 upvotes 5 months ago

Oral minoxidil is effective for hair loss but may cause side effects like increased heart rate and edema. Finasteride is recommended, with dutasteride as an alternative if needed.

community Starting minoxidil and looking for a few tips

in Minoxidil 7 upvotes 5 months ago

The conversation is about using minoxidil for diffuse thinning after finasteride showed no regrowth. Tips include applying minoxidil directly to the scalp, considering potential shedding, and being cautious with combining tretinoin due to possible irritation.

community 4 months of restarting treatment. M36

in Progress Pictures 58 upvotes 6 months ago

A 36-year-old man restarted hair loss treatment after a break, using topical Minoxidil 5% twice daily, topical Finasteride 0.01% daily, and Ketoconazole 2% three times a week, along with supplements like Vitamin B12, D3, C, Biotin, Omega-3, zinc, and copper. He avoids oral Finasteride due to side effects and plans to evaluate progress after a year.

community Do people still use microneedling?

in Treatment 10 upvotes 8 months ago

Microneedling is still considered effective for hair growth, especially when combined with minoxidil, though it is time-consuming. Some users report significant success with consistent use, while others find it less popular due to the effort required compared to topical treatments alone.

community Progress check - 6 months apart.

in Is this regrowth? 36 upvotes 11 months ago

The conversation is about a user's hair loss treatment regimen, which includes daily finasteride, topical minoxidil, derma rolling, and Nizoral shampoo. Opinions vary on the effectiveness of the regimen, with some users suggesting additional treatments like oral minoxidil and dutasteride, while others debate the presence of a scalp fungus and the impact of microneedling.

community Oral Minoxidil- Be Careful!!!!!

in Minoxidil 417 upvotes 11 months ago

Oral minoxidil can cause severe side effects, including heart issues, even at low doses. Users suggest starting with a lower dose or using topical treatments to minimize risks.

community Let’s talk about micro needling

in Microneedling 14 upvotes 1 year ago

Microneedling combined with minoxidil is more effective for hair growth than microneedling alone. Optimal results are seen with weekly microneedling using 0.5 - 1mm needles and regular minoxidil application, avoiding minoxidil on the needled area for 24 hours.

community Hair transplant, 3 month progress

in Is this regrowth? 213 upvotes 1 year ago

The user experienced hair loss after a hair transplant and stopped using finasteride and minoxidil temporarily, as advised by their medical team. They resumed the treatments and are hopeful for regrowth, attributing the current hair loss to shock loss and shedding.

community A list of top hyperresponders of /tressless with a data array for studying the phenomenon

in Research 155 upvotes 1 year ago

The conversation is about treatments for androgenetic alopecia, focusing on hyperresponders. Treatments include Minoxidil, finasteride, RU58841, leg training, and cold therapy.

community Good Progress Results 7 Months 1mg Finasteride 2.5mg minoxil [22M]

in Progress Pictures 142 upvotes 2 years ago

A user shared progress pictures showing significant hair growth after 7 months of using 1mg finasteride and 2.5mg minoxidil. The user also noted improved beard growth.