community Has anyone seen this study before? It claims that B6+Zinc can inhibit 5ar activity
The conversation discusses using B6 and Zinc to inhibit 5ar activity, similar to Fin and Dut. Minoxidil is mentioned as a supplementary treatment.
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30 / 408 resultscommunity Do finasteride/dutasteride actually inhibit only 40/50% scalp DHT
Finasteride works by reducing DHT, which helps stop hair miniaturization. The user is on finasteride and believes it works due to its effect on growth factors and DHT reduction.
community Bile Acid-Mediated DHT Dysregulation Hypothesis
Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.
community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?
Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.
community The mechanism of androgenic alopecia
DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.
community Daily aspirin is ruining your Min. gains
Aspirin reduces the effectiveness of minoxidil for hair loss. Quercetin and 5-ASA medications also inhibit the necessary enzyme for minoxidil to work.
community Theoretically won't this be better than finasteride? Azelaic acid + zinc
The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.
community A less common type of hairloss case
High-dose Lysine and Histidine supplements caused curly/kinky hair and shedding due to Elastin dysfunction. Minoxidil, white tea, and dark grape juice were mentioned as treatments to inhibit Elastase and mimic Lysyl Oxidase.
community He is claiming, he can treat alopecia
A user claims a product can treat alopecia, but others are skeptical, calling it a scam due to lack of evidence and transparency. The product is said to inhibit Type II 5-αr by 22.9%, but is considered weaker than existing DHT blockers.
community Beard growth whilst on Dutastride
Dutasteride may inhibit new beard growth, but minoxidil can still promote beard growth, albeit slowly. Some users report thicker beards with oral minoxidil despite using dutasteride.
community Clotrimazole a better anti-androgen than Ketoconazole?
Clotrimazole may inhibit testosterone better than Ketoconazole. The user considers applying Clotrimazole cream on the scalp for hair loss.
community mangifera indica (mango oil) inhibits dkk1, dht TYPE 2 and activate wnt signal in vivo
Mango oil may inhibit DKK1 and DHT, potentially aiding hair growth by activating the Wnt signaling pathway. A user plans to test mango leaves juice and other Ayurvedic products for hair regrowth.
community Verteporfin day 119 update - donor hair regeneration human trial
A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.
community Does Vitamin C serum negate the the collagen reduction that Minoxidil causes?
Minoxidil can inhibit collagen production, potentially causing premature aging. The user is inquiring if Vitamin C serum or derma rolling can counteract this effect.
community Ultimate Stack without nuking your gender (you'll go broke)
A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.
community Nizoral ketaconazole any good for dht reduction
A 17-year-old is looking for alternatives to finasteride for DHT control to preserve hair, considering ketoconazole shampoo for its potential to inhibit 5AR and also thinking about using caffeine-containing shampoos like alpecin or watermans.
community Painkillers May Block Minoxidil
Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.
community Why do we only talk about 0.5mg or 2.5mg Dutasteride? What about 1? 1.5??
Increasing Dutasteride dosage from 0.5mg to 1.5mg may inhibit more scalp DHT, but the exact benefit is unclear. Combining Dutasteride with leftover Finasteride might not provide additional benefits.
community Does caffeine inhibit 5-α-reductase?
Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.
community A Novel Synergistic Strategy for Hair Loss Prevention and Reversal: Rapamycin, Finasteride, and Minoxidil
Rapamycin, finasteride, and minoxidil are discussed as a strategy for hair loss prevention and reversal. Pulsed dosing of rapamycin is suggested to avoid conflicting effects with minoxidil.
community B6,Zinc and acid azelaic inhibit 90% of scalpe DHT according to this study how to make the same topical formulation
The conversation is about creating a topical hair loss treatment with B6, zinc, and azelaic acid, which is claimed to inhibit 90% of scalp DHT. One user is skeptical about the effectiveness of this treatment and its comparison to other treatments without side effects.
community 1mg and .5mg finasteride inhibit roughly the same amount of DHT, but have studies ever directly compared the two when just looking at regrowth?
The conversation is about whether taking 0.5mg of finasteride daily is as effective as 1mg for hair regrowth and if there are long-term studies supporting the lower dose. The user is considering the lower dose to save money and reduce concerns about side effects.
community Could the salicylic acid in my Nioxin shampoo reduce minoxidil effectiveness?
Salicylic acid in Nioxin shampoo may reduce minoxidil effectiveness by inhibiting sulfotransferase activity, potentially causing hair loss. Users suggest stopping salicylic acid use or trying alternative treatments like high-concentration tretinoin or medicated minoxidil/finasteride shampoos.
community Targeting multiple AGA mechanisms with commonly available substances
The conversation discusses using a multimodal approach to treat androgenic alopecia, including substances like gamma-linolenic acid, DHA, sulforaphane, melatonin, cetirizine, astaxanthin, fisetin, apigenin, curcumin, limonene, genistein, and berberine. Users also mention using ketoconazole, minoxidil, and low-level laser therapy (LLLT) as part of their hair loss treatment regimens.
community Has anyone ever used grape seed extract? Any negative effects on hair ?
The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.
community Dutasteride actually has different half lives depending on dose
Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.
community Cassiopea announces completion of recruitment of Phase II dose ranging trial of Breezula (CB-03-01) for androgenic alopecia
The conversation discusses the completion of a Phase II trial recruitment for Breezula (CB-03-01), a potential treatment for androgenic alopecia. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.
community Anyone used or have experience with this product from eSurgery?
The conversation is about using a topical hair loss treatment from eSurgery containing finasteride, minoxidil, and tretinoin. The user is seeking recommendations and experiences with this specific product.
community Salicylic Acid shampoo while on minoxidil. Is it okay?
Minoxidil users can safely use salicylic acid shampoo to manage scalp pimples and dandruff. Nizoral is also recommended for hair gain and treating scalp pimples.
community We need actual hair loss studies on Epristeride
Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.