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GlossaryHepcidin

hormone regulating iron absorption and release in the body

Hepcidin is a hormone produced by the liver that plays a crucial role in regulating iron levels in the body. It controls the absorption of iron from the diet and its release from storage sites, ensuring that iron levels remain balanced. Elevated hepcidin levels can lead to conditions like anemia, while low levels can cause iron overload disorders.

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research miR-761-hepcidin/Gpx4 pathway contribute to unexplained liver dysfunction in polycystic ovary syndrome by regulating liver iron overload and ferroptosis

16 citations , January 2023 in “Gynecological Endocrinology”

Liver damage in PCOS is linked to iron overload and cell death due to the miR-761-hepcidin/GPX4 pathway.

research The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron.

9 citations , November 2007 in “Blood”

TMPRSS6 is crucial for controlling hepcidin and normal iron absorption.

research Matriptase-2, A Novel Suppressor of Hepcidin.

November 2009 in “Blood”

Matriptase-2 helps control iron levels by suppressing hepcidin, and its deficiency can cause iron-deficiency anemia.

research Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

245 citations , January 2010 in “Blood”

Antihepcidin antibodies may treat inflammation-induced anemia by improving iron metabolism.

research Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone

53 citations , July 2014 in “American Journal of Physiology-Endocrinology and Metabolism”

Testosterone boosts red blood cell production and changes iron metabolism without needing dihydrotestosterone.

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