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GlossaryKeratotic Plugs

small, hardened accumulations of keratin blocking hair follicles

Keratotic plugs, also known as keratin plugs or follicular plugs, are small, hardened accumulations of keratin and dead skin cells that block hair follicles. These plugs can lead to conditions like keratosis pilaris, where the skin becomes rough and bumpy, often resembling goosebumps. They are commonly found on the upper arms, thighs, and buttocks, and can sometimes cause inflammation or irritation.

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community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Oral Minoxidil - Multiple Facial Hair in One Follicle / Pili Multigemini Question

in Minoxidil 117 upvotes 5 months ago

Oral minoxidil can cause multiple facial hairs to grow from one follicle, known as Pili Multigemini, leading to ingrown hairs and zits. Users report increased facial and body hair growth, with some experiencing fewer issues after switching to dutasteride.

community Dermatologist says you can’t prevent hair loss and medications don’t work

in Research/Science 142 upvotes 7 months ago

Finasteride, dutasteride, and minoxidil can help prevent or slow hair loss for many, though results vary. The dermatologist's claim that no medication works is incorrect, as these treatments are effective for some individuals.

community What are these spots on my scalp

in Treatment 51 upvotes 1 year ago

A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

community When you're balding is it an absolute traumatic period of your life or do some people not care as much?

in Chat 89 upvotes 1 year ago

Balding can be traumatic for many, affecting self-esteem and social interactions, while others accept it more easily. Treatments mentioned include finasteride, minoxidil, and RU58841.

community Bryan Johnson just dropped his anti hair loss formula

in Treatment 340 upvotes 2 years ago

Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

community 22M Fin and min everyday for 10 months, looks like my right temple is still receding

in Finasteride/Dutasteride 67 upvotes 2 years ago

The user is seeking opinions on their hair loss, specifically the receding of their right temple. They are considering switching to Dutasteride but are unsure if it will help. Other users suggest that their hairline has improved with the use of Finasteride and Minoxidil. One user mentions using RU58841 to thicken their hairline.

community My skin is always dry and flakes like chalk (25)

in Transgender 6 upvotes 2 years ago

The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

community Is Finasteride helping with my skin tags or is it something else?

in Treatment 3 upvotes 1 year ago

The user noticed improvement in skin tags after using oral and topical finasteride and minoxidil, along with other supplements like thiamine, P5P, serrapeptase, nattokinase, and retinol. They are unsure which treatment caused the improvement and are seeking input on whether finasteride's DHT reduction could be responsible.

community My Experience and a Discourse on "DUPA"

in Treatment 9 upvotes 1 year ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

community Eliminating scalp itch leads to regrowth (and my RU58841 progress)

in Research/Science 61 upvotes 2 years ago

User experienced hair regrowth after eliminating scalp itch with RU58841. Others discussed itch and hair loss connection, and effectiveness of combining RU58841 with 5AR inhibitors.

community The hardest hair protocol ever!

in Research/Science 11 upvotes 3 years ago

The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

community Losing Hair on Dutasteride? You might have LPP

in Research/Science 96 upvotes 1 year ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

community Sharing my progress over the years, also some recent struggle on RU58841 and crazy shed.

in Progress Pictures 48 upvotes 2 years ago

Matt-3422 shared his hair loss treatment journey, starting with great results from Minoxidil and oral Finasteride, then switching to RU58841 and topical Finasteride due to worsening hair loss. He's experiencing scalp irritation and is unsure if he should continue with his current regimen, while others suggest scalp care and alternative treatments.

community Anyone heard of scube3? And other emerging treatments?

in Research/Science 4 upvotes 1 year ago

Emerging hair loss treatments like PP405, a topical MPC inhibitor, show promise in activating stem cells for hair growth. The conversation seeks information on the development stages and accessibility of these treatments.

community Pyrludimide (KX-826) or Breezula (clascoterone)

in Treatment 9 upvotes 1 month ago

The conversation is about hair loss treatments, specifically Pyrludimide (KX-826) and Breezula (clascoterone), with the user unable to tolerate finasteride and dutasteride. The user plans to use these treatments alongside minoxidil, considering the efficacy and availability of each option.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community Fear of transplants because of 'the old plugs' of yesteryear.

in Transplants 22 upvotes 7 years ago

Hair transplants have improved significantly from the old "plug" method, which left unnatural results. Modern techniques by skilled doctors can achieve natural-looking hairlines.

community Pelage Recruiting Now for Phase 2

in Research/Science 11 upvotes 1 year ago

Pelage is recruiting for phase 2 trials, showing promise for treating bald regions. The discussion highlights its potential effectiveness based on its mechanism of action.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community SCUBE3/Pyr/or anything else of interest in the piplines. any updates?

in Research/Science 11 upvotes 3 years ago

Hair loss treatments discussed include promising Pyr available online and Verteporfin dosing after FUE for follicle regeneration, but no updates on SCUBE3.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 122 upvotes 6 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community Microneedling versus Platelet-Rich Plasma

in Research/Science 10 upvotes 7 months ago

Microneedling and Platelet-Rich Plasma (PRP) are equally effective for treating androgenetic alopecia, with no additional benefits from PRP over microneedling. Both treatments are safe and well-tolerated.

community Clascoterone study going on right now

in Research/Science 353 upvotes 2 years ago

A user is participating in a phase 3 trial for Clascoterone, a topical acne medication that may stimulate hair growth, and will share results after 6 months. They will have a section of their hair shaved and marked with a tattoo for the study.

community Micro needling and ptd-dbm progress

in Progress Pictures 5 upvotes 4 years ago

The conversation is about using micro needling and PTD-DBM for hair loss treatment. The user applies PTD-DBM drops on weekdays and performs micro needling weekly.

community Hair and normal skin created from human pluripotent stem cells for the first time

in Update 86 upvotes 5 years ago

Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.

community Clascoterone for hair loss. Promising study.

in Treatment 11 upvotes 5 months ago

A new topical medication, Clascoterone, shows promise for hair loss, improving hair count significantly. Trials for Breezula are ending, but sign-ups for PP405 trials are available for 2026.

community Post Low-Level Laser Light Therapy Syndrome (PLLLTS )

in Satire 6 upvotes 3 years ago

Hair loss discussion includes LLLT treatments and a satirical condition called PLLLTS, causing patients to resemble lighthouses and attract moths. Some users express concern about others taking the satire seriously.

community Injured temple with derma rolling

in Microneedling 2 upvotes 1 year ago

OP injured their temple using derma rolling and tretinoin, causing peeling and potential hair follicle damage. Users suggest the injury might be permanent, possibly resulting in scar tissue where hair won't grow.

community DHT itch, dandruff and sebum plugs.

in Hair Systems 1 upvotes 5 years ago

The conversation discusses hair loss treatments, focusing on reducing scalp itching and dandruff using natural shampoos, witch hazel, and apple cider vinegar. The user also mentions using finasteride and observing potential regrowth, though it's difficult to confirm.