The user observed some regrowth and longer baby hairs after one month of using finasteride, despite experiencing increased shedding. They noted no side effects except for clear semen.
After 2.5 years of using 1mg finasteride daily, 5% minoxidil foam twice daily, and weekly micro-needling, the user reports thicker, healthier hair without further loss. They noticed initial regrowth at 3 months, with significant improvement up to 18 months, and no negative side effects from the treatment.
The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.
Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.
Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.
The user discusses using finasteride (1mg every other day) and topical minoxidil once a day for hair regrowth over 90 days. They are inquiring about the effectiveness of this treatment for hair regrowth.
The user plans to stop using finasteride due to side effects but will continue using minoxidil. They are concerned about hair regrowth without finasteride.
Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.
The user experienced scalp inflammation and rapid hair loss after using minoxidil, despite initial success. Suggestions included switching to minoxidil foam, using oils, trying aspirin, and considering RU58841 for inflammation and hair loss management.