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GlossaryMetallothionein

protein that binds heavy metals, aiding detoxification and regulation

Metallothionein is a type of protein that binds to heavy metals like zinc, copper, and cadmium, helping to regulate their levels in the body and protect cells from metal toxicity. It plays a crucial role in metal ion metabolism and detoxification, and is also involved in the body's response to oxidative stress.

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community What Determines Sulfotransferase Enzyme Levels In The Body?

in Minoxidil 7 upvotes 1 year ago

Some people have low sulfotransferase enzyme levels, affecting their response to minoxidil. Lifestyle factors, genetics, and diet, like MSM intake, might influence these enzyme levels.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Did these tests—any of these linked to diffuse thinning?

in Research/Science 4 upvotes 1 year ago

A 25-year-old male experiencing diffuse thinning is advised to address high TSH levels and low iron, and consider treatments like finasteride. Weight loss and improved diet are also suggested to potentially help with hair health.

community Ferritin, iron and testosterone

in Chat 4 upvotes 2 months ago

Dutasteride may affect testosterone levels, leading to high ferritin and iron levels, which can cause hair loss. High ferritin might be linked to past heavy drinking or hemochromatosis.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 3 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Other sulfurtransferase activity upregulator other than Tretinoin?

in Minoxidil 8 upvotes 2 years ago

The user does not respond well to minoxidil and is seeking an alternative to Tretinoin to upregulate sulfurtransferase activity for hair loss treatment. No specific alternative treatments were mentioned.

community Iron, Anemia, DNA testing, and bloodwork

in Research/Science 2 upvotes 9 months ago

The conversation discusses personal experiences with hair loss and highlights the potential impact of anemia and nutrient deficiencies on hair health. Treatments mentioned include changing shampoo/conditioner, taking MSM, collagen, hyaluronic acid, astaxanthin, B12, folate, and bovine blood capsules.

community Iron supplement worked better than Minoxidil. Check your ferritin, even "normal" is low

in Technology 67 upvotes 9 months ago

Iron supplementation may be more effective than Minoxidil for hair loss. Checking ferritin levels is important, as both low and high levels can affect health.

community I literally can’t find any evidence of sulfotransferase being upregulated by microneedling or retinoids like tretinoin

in Research/Science 4 upvotes 10 months ago

Microneedling and tretinoin may enhance minoxidil absorption for hair loss, but evidence on their effectiveness is limited. Iron supplements and broccoli sprouts are suggested for enzyme activation, but their impact on hair is unclear.

community Mineral deficiencies vs MPB vs Thyroid

in Chat 9 upvotes 1 year ago

The user experienced hair improvement using a topical finasteride, minoxidil, and tretinoin combo, along with supplements like zinc, copper, magnesium, vitamin D3, K2, iodine, and boron. They believe these changes are due to addressing mineral deficiencies and possibly thyroid issues, despite skepticism from others.

community GT20029. Kintor Pharma’s Product

in Research/Science 12 upvotes 3 years ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Finasteride with Low Ferritin and Copper

in Finasteride/Dutasteride 3 upvotes 9 months ago

The user is experiencing hair loss and is using finasteride while addressing low ferritin and copper levels. They are concerned about continued hair shedding and are advised to correct vitamin deficiencies and wait for finasteride results after 12 months.

community I got my blood test results, my Thyroid and Ferritin are good but Vitamin D is 11.1 I started topic minoxidil yesterday (5%)

in Treatment 5 upvotes 2 months ago

The user has androgenetic alopecia (AGA) and low Vitamin D levels, and they started using topical minoxidil (5%). They are considering finasteride but are concerned about side effects and are advised to seek mental health support.

community Trichotest results in… min not on my list! Just Fin/Dut, Zinc… and the insanely expensive latanoprost & prostaquinon.

in Technology 22 upvotes 4 years ago

Hair loss discussion includes treatments like hinoki tree oil and procyanidin b2. Experiences and effectiveness of these treatments are shared.

community Could Serum Ferritin Explain my Crazy Shedding?

in Treatment 1 upvotes 6 months ago

The user is experiencing significant hair shedding and suspects it may be due to low serum ferritin levels rather than worsening androgenetic alopecia. They have resumed iron supplementation and are seeking additional solutions to address the shedding.

community MSM Supplementation is helping my hairs

in Update 4 upvotes 3 months ago

The user reports that MSM supplementation has thickened their hair strands while using finasteride and topical minoxidil. They also take zinc, copper, B-complex, vitamin C, vitamin D3, and K2, and plan to add omega-3, magnesium, astaxanthin, and pterostilbene.

community Severe copper deficiency, and also zinc deficiency. Looking for testimonials.

in Research/Science 2 upvotes 6 months ago

A 36-year-old man with androgenetic alopecia suspects copper and zinc deficiencies may be accelerating hair loss and is supplementing copper to address this. He is also monitoring blood sugar levels due to previous prediabetes concerns and plans to test for insulin resistance.

community Diffuse Thinning From Low Iron and Thyroid -Finally Seeing Regrowth After Fixing the Root Cause

in Female 26 upvotes 7 months ago

A female experienced hair loss due to low iron and an undiagnosed thyroid issue, specifically Hashimoto's, and saw improvement after starting thyroid medication, iron supplements, and making lifestyle changes. She emphasizes the importance of addressing the root cause and shares her journey to regrowth and emotional recovery.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community Naturally high T (1,100+) causing diffuse thinning while on Dut

in Chat 22 upvotes 2 months ago

A 26-year-old male with high testosterone is experiencing diffuse hair thinning despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy. Suggestions include adjusting dutasteride dosage, monitoring iron levels, and consulting a dermatologist for further evaluation.

community Anyone here have experience with ferritin level and hair?

in Treatment 4 upvotes 4 months ago

Low ferritin levels can affect hair density, and increasing ferritin through iron supplements may help with regrowth. It's suggested to maintain ferritin levels between 70-100 ng/mL and check other micronutrients for optimal hair health.

community Methionine? Glycine?

6 upvotes 10 years ago

The conversation discusses the potential benefits and risks of using Methionine and Glycine for hair loss, with concerns about cancer risk if not balanced properly. The user seeks opinions on these amino acids for hair health and overall benefits.

community Been diagnosed with mpb and acute TE

in Chat 2 upvotes 9 months ago

A 21-year-old male diagnosed with telogen effluvium and male pattern baldness started taking finasteride, which initially slowed hair shedding and slightly thickened hair. The doctor recommended iron and vitamin D supplements, and the user is considering minoxidil but wants to stabilize shedding first.

community AA and Hirsutism but T levels are normal

in Female 5 upvotes 5 years ago

27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

community What hormones/vitamins should I test for?

in General 51 upvotes 11 months ago

The user plans to test for DHT, total testosterone, free testosterone, E2, SHBG, and prolactin while supplementing with vitamin D and monitoring ferritin levels. They are experiencing hairline thinning and are seeking advice on whether their approach is excessive or lacking.

community I have started taking iron polymaltose and my hair has drastically stopped falling out.

in Research/Science 13 upvotes 5 years ago

A user reported that taking iron polymaltose significantly reduced their hair loss. They also mentioned hair loss due to DHT and asked if hair loss from iron deficiency is permanent or temporary.

community Iron Overload and Vitamin D Deficiency - Male Hair Loss

in Treatment 18 upvotes 4 years ago

The conversation discusses hair loss treatments, specifically minoxidil, vitamin D supplements, and the potential impact of iron overload. The user experienced hair regrowth with high-dose vitamin D but faced hair thinning again after reducing the dosage, and is now exploring the role of iron overload in hair loss.

community Micronutrient testing, deficiencies, etc.

in Treatment 4 upvotes 4 years ago

Micronutrient testing and deficiencies related to hair loss, particularly androgenetic alopecia (AGA). Discussion includes the impact of iron, selenium, zinc, copper, folate, B12, vitamin E, vitamin D, amino acids, and fatty acids, alongside treatments like dutasteride or finasteride.

community 200mcg Selenium stopped my hairloss

in Is this regrowth? 7 upvotes 2 years ago

A user reported that taking 20mg copper and 200mcg selenium completely stopped their hair loss. The conversation is about hair loss treatments.

community Simulative evaluation of taurine against alopecia caused by stress in Caenorhabditis elegans. - PubMed

4 upvotes 7 years ago

Taurine shows potential in combating hair loss caused by chemical stress, especially when combined with other treatments like finasteride. Finasteride demonstrated better stress-reducing effects in the study.