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      community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

      in Research/Science  215 upvotes 1 year ago
      PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

      community Am I missing something with pp405?

      in Research/Science  32 upvotes 1 year ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

      community So is this the actual trial results for pp405?????

      in Research/Science  92 upvotes 3 months ago
      PP405 shows promising results for hair growth, potentially outperforming finasteride without side effects like erectile dysfunction. Users discuss using treatments like minoxidil, pyrilutamide, nizoral, and alfatradiol while waiting for PP405's availability.

      community Is Sulforaphane really an option?

      in Chat  8 upvotes 5 years ago
      The conversation discusses the potential benefits of Sulforaphane for hair growth, with a suggestion to grow broccoli sprouts for the best results. One user doubts its effectiveness for hair loss but notes its anti-cancer and hormetic benefits.

      community New Study: PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and stimulate natural hair growth by 20%

      in Research/Science  842 upvotes 9 months ago
      PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and increase hair growth by 20% in eight weeks, unlike minoxidil or finasteride. However, skepticism remains about its effectiveness and availability, with concerns about funding and the timeline for broader access.

      community can someone help me identify these pls

      in Treatment 7 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community Finasteride + Ashwagandha. Inputs ?

      in Research/Science  8 upvotes 3 years ago
      Finasteride and Ashwagandha are discussed as potential treatments for hair loss, with mixed opinions on Ashwagandha's effectiveness and safety. Some users report no benefits from Ashwagandha, while others caution against its use due to potential liver issues.

      community Hairline loss

      8 years ago
      A 20-year-old female is experiencing hairline loss and seeks effective natural remedies or affordable drugstore treatments. She has tried flax seeds and aloe vera without success.

      community Vitamin C and hair growth PH levels

      in Product  33 upvotes 4 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community New molecule PP405 vs exercise

      in Research/Science  38 upvotes 1 year ago
      PP405 targets hair follicle stem cells differently than exercise-induced lactate, suggesting exercise alone may not replicate its benefits. Minoxidil and finasteride are recommended alongside exercise for hair regrowth, with additional suggestions like spicy food and infrared exposure.

      community Dry and itchy scalp after ru58841 and keto. Advice needed

      in Product  3 upvotes 4 years ago
      The user experienced severe scalp itching after using RU58841 and ketoconazole shampoo, despite trying moisturizing treatments. They suspect the issue is related to the propylene glycol in the vehicle and are seeking alternatives.

      community Is the juice worth the squeeze? I'm concerned about density.

      in Progress Pictures 8 months ago
      The user is using biotin, pumpkin seed oil, saw palmetto, green tea, Minoxidil, Nizoral shampoo, and derma rolling to combat hair loss but is hesitant to use finasteride due to potential side effects. Others suggest that without finasteride or dutasteride, the natural approach is unlikely to be effective long-term.

      community Sooo whats the consensus about pp405 now?

      in Chat  75 upvotes 3 months ago
      PP405 may help with hair regrowth, especially when combined with minoxidil and finasteride, but its long-term effectiveness is unclear. Phase 3 trials are expected to begin soon, with results in a few years.

      community hair loss treatment alternatives and ideas to improve gain

      in Treatment  3 upvotes 3 years ago
      The post discusses using finasteride, minoxidil, ketoconazole, and a dermaroller for hair loss, along with spearmint capsules, pueraria mirifica, saw palmetto, biotin, and vitamins. The user is also considering microdosing finasteride with trans treatment and mentions the potential of herbal enemas and hair systems.

      community after several weeks of research, here's the stack I've decided on

      in Finasteride/Dutasteride  43 upvotes 1 year ago
      A 23-year-old experiencing diffuse hair thinning has chosen a treatment stack including topical finasteride, a blend of rosemary, peppermint, and pumpkin seed oils, procyanidine B2 spray, ketoconazole shampoo, and scalp massages. They avoid minoxidil due to family history of side effects and oral finasteride due to high estrogen levels.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  50 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community If PP405 works it will be fkn impossible to buy it.

      in Technology  102 upvotes 7 months ago
      PP405 is a potential hair loss treatment that may activate dormant hair follicles, but there are concerns about its effectiveness, cost, and side effects. Users discuss treatments like minoxidil, finasteride, and RU58841, expressing skepticism about PP405's long-term success and accessibility.

      community Why Didn't the Pumkin Seed Oil Study Get More Attention?

      in Question  71 upvotes 7 years ago
      Pumpkin seed oil showed a 40% increase in hair count, but its effectiveness is questioned due to other ingredients in the supplement. Users discuss its potential compared to finasteride, with some expressing skepticism and others showing interest.

      community Is there new research about pumpkin oil as a DHT blocker (2026)?

      in Research/Science  9 upvotes 1 month ago
      Pumpkin seed oil is considered a weak DHT blocker compared to finasteride and dutasteride, with some users reporting side effects like mood changes and reduced libido. Despite some anecdotal benefits for urinary issues, it is not effective for hair loss, and finasteride is preferred by some users for its lack of side effects.

      community Fixing DHT Itch (scalp inflammation) with Aloe Vera gel & more

      in Research/Science  13 upvotes 11 months ago
      Aloe vera gel can help reduce scalp inflammation and "DHT itch" associated with hair loss, particularly in those with androgenic alopecia and seborrheic dermatitis. It's suggested to use aloe vera alongside treatments like finasteride and ketoconazole shampoo to manage symptoms and promote scalp health.

      community Question.. ( Come check )

      6 years ago
      A user has been losing hair for two and a half years after a tropical trip and illness. A dermatologist prescribed betamethasone valerate 0.1% lotion, but the user is unsure if it's safe or effective for general hair loss.

      community Natural hair loss holy grail? Looks good to me.

      in Product 1 year ago
      The conversation discusses using natural alternatives like saw palmetto, pumpkin seed oil, pygeum, and nettle extract for hair loss, alongside treatments like nizoral, dermastamp, red light, and rosemary oil. Opinions vary, with some users skeptical about the effectiveness compared to finasteride, and concerns about potential side effects.