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GlossaryPheomelanin

pigment responsible for red and yellow hues in hair

Pheomelanin is a type of melanin pigment found in human hair and skin that gives them a reddish or yellowish hue. It is one of the two main types of melanin, the other being eumelanin, which is darker. Pheomelanin is more prevalent in individuals with lighter skin and hair, and its presence can influence the overall color and tone of these features.

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community Optimal dose for topical Melatonin

in Treatment 4 upvotes 2 years ago

The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

community It looks like Pelage are giving hints that PP405 is a game changer

in Chat 239 upvotes 2 weeks ago

PP405 is seen as a potential breakthrough for converting vellus hairs to terminal hairs, with users expressing both hope and skepticism. It is compared to treatments like minoxidil and finasteride, with discussions on side effects and marketing concerns.

community Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics

in Research 47 upvotes 1 year ago

Rhamnose may promote hair growth and pigmentation, suggesting it as a potential hair loss treatment. The conversation discusses its potential alongside known treatments like Minoxidil, finasteride, and RU58841.

community I've been using Toppik for the past couple weeks and really like it, but I need some help

in Update 10 upvotes 6 years ago

User tried Toppik hair fibers and liked the results, but hairspray darkened the color. They asked for advice on Toppik brand spray or alternatives that don't darken hair color.

community Topical melatonin/oral

in Research/Science 12 upvotes 5 years ago

The conversation discusses the potential positive effects of melatonin on hair growth. The original poster plans to try both oral and topical melatonin and is seeking recommendations for a good source.

community Scalp Micropigmentation while having hair

in Treatment 6 upvotes 4 years ago

User discusses scalp micropigmentation for denser hair appearance and its benefits compared to lifelong treatments. Special ink is used, which can fade and blur over time but can be topped up.

community PP405 Identity Research

in Research 292 upvotes 7 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community Does anyone know the chemical formula for pelage pp405?

in Research/Science 14 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community People who taking melatonin, do you have any grey hairs?

in Research/Science 11 upvotes 2 years ago

The post discusses the theory that melatonin could reverse grey hair by regulating certain enzymes. However, users who have taken melatonin reported no effect on preventing or reversing grey hair.

community Do-it-yourself topical melatonin?

in Product 12 upvotes 3 years ago

The conversation is about creating homemade topical melatonin for hair loss, with one person suggesting adding melatonin to stemoxydine as a potential treatment.

community Okay to add melatonin powder to the topical finasteride solution?

in Finasteride/Dutasteride 13 upvotes 2 years ago

The conversation discusses adding melatonin powder to a topical finasteride solution for hair loss, with one reply suggesting that melatonin may promote faster hair growth but advising against mixing it directly into the solution due to potential instability.

community UCLA scientists found a molecule — PP405 — that wakes up sleeping hair follicles and tells them, “Do your job.”

in Research/Science 1350 upvotes 11 months ago

PP405 is a promising molecule that may reactivate dormant hair follicles, potentially offering a new treatment for hair loss. It is in phase 2 trials, with possible availability between 2027 and 2030.

community Compounding Topical Melatonin at Home

in Treatment 8 upvotes 4 years ago

Melatonin at a 0.0033% concentration shows results for hair loss when used topically. A user is discussing how to replicate this by adding 2mg of Melatonin to 60ml of Minoxidil solution.

community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026

in Research/Science 1046 upvotes 2 weeks ago

PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.

community Those that are using topical melatonin--how often do you use it?

in Product 7 upvotes 3 years ago

People are discussing the use of topical melatonin for hair loss and how often it should be applied, with one person noting it makes them groggy in the morning. They are inquiring about others' application frequency.

community On the topic of HMI-115 and prolactin: has anyone tried adding Vitamin B6 (P-5-P) to their topical solutions?

in Research/Science 7 upvotes 2 years ago

The conversation discusses the potential benefits of adding Vitamin B6 (P-5-P) to topical hair loss treatments like RU58841, finasteride, or minoxidil. The user suggests that Vitamin B6 might enhance these treatments by naturally lowering scalp prolactin.

community How are you using topical melatonin?

in Treatment 1 upvotes 2 years ago

The user is experimenting with topical melatonin for hair loss by dissolving melatonin tablets in a solution, but is having trouble with dissolution and is curious about others' methods of application and any effects on energy levels. They mention considering mixing with minoxidil but have not done so, and suggest that melatonin is best used at night.

community Topical latanoprost chance of eye color change?

in Product 1 upvotes 1 year ago

The user is using oral minoxidil for hair growth and is considering adding topical latanoprost, but is concerned about potential eye color change. They are seeking advice on the effectiveness of latanoprost for hair thickening and the risk of eye color change.

community Approve PP405 quickly you coward

in Satire 193 upvotes 9 months ago

Pelage Pharmaceuticals is developing PP405, a topical treatment for hair growth, currently in Phase 2a trials. There is skepticism about the company's claims, and no fast-tracking approval timeline has been detailed.

community Anyone experimenting with Melatonin?

in Treatment 5 upvotes 4 years ago

Melatonin is being explored as a hair loss treatment, with one user mixing it into minoxidil but not seeing results. The conversation discusses experimenting with melatonin concentrations.

community Pirfenidone - The answer to fibrosis and baldness

in Treatment 20 upvotes 4 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community Pelage, PP405, is creating a database for potential new trial volunteers

in Research/Science 149 upvotes 6 months ago

PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.

community A vehicle for powdered melatonin

in Treatment 6 upvotes 4 years ago

The conversation is about using topical melatonin for hair loss and seeking advice on a safe mixing solution or pre-mixed product. Specific treatments mentioned are minoxidil, finasteride, and RU58841.

community IGF-1 and Peptides? Miracle molecule waiting to be found

in Research/Science 10 upvotes 7 months ago

The conversation discusses potential hair loss treatments focusing on stimulating IGF-1 at the follicle level using growth-factor cocktails and engineered peptides, such as Acetyl Tetrapeptide-3, Copper Tripeptide-1, Oligopeptide-20, Thymosin-β4, and Palmitoyl Tetrapeptide-7. It suggests that device-assisted delivery methods like microneedling may enhance effectiveness.

community PP405 Update and My Take on Pelage

in Research/Science 86 upvotes 5 months ago

Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

community Pelage Announces Positive Results of Phase 2a Trials for PP405

in Update 300 upvotes 9 months ago

PP405 shows promise in treating severe hair loss, with 31% of users experiencing over 20% hair density increase in four weeks, faster than minoxidil and finasteride. Some users are skeptical about the results' significance and long-term efficacy.

community PELAGE PHASE 2 TRIALS FOR PP405 - Volunteers Needed

in Research/Science 25 upvotes 1 year ago

PP405 is a topical gel being tested for hair regrowth in adults with androgenetic alopecia. Volunteers aged 18-55 are needed for a 16-week trial in several US locations.

community Reminder to add melatonin to your topical solutions (or to min if you take fin orally)

in Treatment 4 upvotes 2 years ago

Adding melatonin to minoxidil can improve hair growth and thickness, and it's easy to use with minimal side effects. The recommended concentration for melatonin in the solution is between 0.05% and 0.2%.

community Has anyone tried this new peptide ghk-cu?

in Treatment 5 upvotes 8 months ago

People are discussing the use of the peptide GHK-Cu for hair and skin, with mixed results. Some users have tried it alongside other treatments like adenosine and melatonin, but have not seen significant improvements, and one user stopped due to cost.

community Topical Melatonin for mild aga

in Chat 2 upvotes 2 years ago

The conversation is about an 18-year-old male considering topical finasteride for hair loss and asking about the effectiveness of topical melatonin for hair regrowth and density. No specific treatments were confirmed to be used.